clobutinol

Also known as KAT-256 [As Hydrochloride]

Clobutinol is a cough suppressant formerly distributed by Boehringer Ingelheim and its licensees under the names Lomisat and Silomat, by Bioter as Biotussin, and by Violani-Farmavigor as Pertoxil. It has been withdrawn from the market worldwide.

Research

46 papers

Clobutinol delays ventricular repolarization in the guinea pig heart: comparison with cardiac effects of HERG K+ channel inhibitor E-4031.Journal of cardiovascular pharmacology · 2009
A common antitussive drug, clobutinol, precipitates the long QT syndrome 2.Molecular pharmacology · 2004
[Clobutinol-sensitive electrode (author's transl)].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan · 1979
Clobutinol: severe cardiac arrhythmias. Old drugs should also be monitored.Prescrire international · 2008
[Risks of non-prescription medication. Clobutinol cough syrup as a recent example].Deutsche medizinische Wochenschrift (1946) · 2008

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Wikidata facts

Mass: 255.139

Show 3 more facts

chemical formula: C₁₄H₂₂ClNO
Commons category: Clobutinol
canonical SMILES: CC(CN(C)C)C(C)(CC1=CC=C(C=C1)Cl)O

Sources (2)

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Article

3 sections

Contents

Side effects and withdrawal
See also
References

==Side effects and withdrawal== Side effects include drowsiness, dizziness, insomnia, nausea, vomiting, and abdominal discomfort. Studies in 2004 had indicated that clobutinol has the potential to prolong the QT interval. Clobutinol was in 2007 determined to cause cardiac arrhythmia in some patients.