Structure via PubChem · Public domain (PubChem)
normethadone
Sign in to saveAlso known as 6-dimethylamino-4,4-diphenyl-3-hexanone, desmethylmethadone, isomethadone I
Normethadone (INN, BAN; brand names Ticarda, Cophylac, Dacartil, Eucopon, Mepidon, Noramidone, Normedon, and others), also known as desmethylmethadone or phenyldimazone, is a synthetic opioid analgesic and antitussive agent. Normethadone is listed under the Single Convention on Narcotic Drugs 1961 and is a Schedule I Narcotic controlled substance in the United States, with a DEA ACSCN of 9635 and an annual manufacturing quota of 2 grams. The salts in use are the hydrobromide (free base conversion ratio 0.785), hydrochloride (0.890), methyliodide (0.675), oxalate (0.766), picrate (0.563), and t
Chemical data
- Formula
- C20H25NO
- Molecular weight
- 295.4 g/mol
- IUPAC name
- 6-(dimethylamino)-4,4-diphenylhexan-3-one
- SMILES
- CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
- InChIKey
- WCJFBSYALHQBSK-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 20.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- Cough
via ChEMBL · EBI
Research
12 papers- [Conformation of normethadone].Archiv der Pharmazie · 1973
- Phenyl-substituted normethadones: synthesis and pharmacology.The Journal of pharmacy and pharmacology · 1995
- Reporting Rates of Opioid-Related Adverse Events Since 1965 in Canada: A Descriptive Retrospective Study.Drugs - real world outcomes · 2022
- Identification and quantitative determination of some metabolites of methadone, isomethadone and normethadone.The Journal of pharmacy and pharmacology · 1971
- Non-opioid antitussives and methadone differentially influence hippocampal long-term potentiation in freely moving rats.European journal of pharmacology · 1993
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 295.193614
- Has use
- medication
Show 3 more facts
- chemical formula
- C₂₀H₂₅NO
- canonical SMILES
- CCC(=O)C(CCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2
- subject has role
- antitussive
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Normethadone (INN, BAN; brand names Ticarda, Cophylac, Dacartil, Eucopon, Mepidon, Noramidone, Normedon, and others), also known as desmethylmethadone or phenyldimazone, is a synthetic opioid analgesic and antitussive agent. Normethadone is listed under the Single Convention on Narcotic Drugs 1961 and is a Schedule I Narcotic controlled substance in the United States, with a DEA ACSCN of 9635 and an annual manufacturing quota of 2 grams. The salts in use are the hydrobromide (free base conversion ratio 0.785), hydrochloride (0.890), methyliodide (0.675), oxalate (0.766), picrate (0.563), and the 2,6-ditertbutylnapthalindisulphonate (0.480).
==See also== Methade
Excerpted from Wikipedia’s “normethadone” article, available under the CC BY-SA 4.0 licence.
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