Structure via PubChem · Public domain (PubChem)
cyclazocine
Sign in to saveCyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. It is in the benzomorphan and benzazocine family of drugs. It is a κ-opioid receptor agonist and μ-opioid receptor partial agonist, and also has high affinity for the δ-opioid receptor.
Chemical data
- Formula
- C18H25NO
- Molecular weight
- 271.4 g/mol
- IUPAC name
- 10-(cyclopropylmethyl)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
- SMILES
- CC1C2CC3=C(C1(CCN2CC4CC4)C)C=C(C=C3)O
- InChIKey
- YQYVFVRQLZMJKJ-UHFFFAOYSA-N
- XLogP
- 2.6
- Polar surface area
- 23.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
1,118 papers- Cyclazocine revisited.Neurochemical research · 1996
- Cyclazocine and congeners.Advances in biochemical psychopharmacology · 1973
- Cyclazocine in the treatment of narcotic addiction.Current psychiatric therapies · 1967
- Cyclazocine and methadone in narcotic addiction.JAMA · 1967
- (+/-)Cyclazocine blocks the dopamine response to nicotine.Neuroreport · 1999
via PubMed
Wikidata facts
- Mass
- 271.194
Show 4 more facts
- chemical formula
- C₁₈H₂₅NO
- canonical SMILES
- CC1C2CC3=C(C1(CCN2CC4CC4)C)C=C(C=C3)O
- subject has role
- opioid antagonist
- Commons category
- Cyclazocine
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- Research
- References
Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine. It is in the benzomorphan and benzazocine family of drugs. It is a κ-opioid receptor agonist and μ-opioid receptor partial agonist, and also has high affinity for the δ-opioid receptor.
== Research == Research into the use of cyclazocine for the treatment of bipolar patients with depression was undertaken by Fink and colleagues (1970). It showed that 8 out of 10 patients experienced moderate improvement.
Excerpted from Wikipedia’s “cyclazocine” article, available under the CC BY-SA 4.0 licence.