allylestrenol
Sign in to saveAlso known as Allyloestrenol, Allyl estrenol, Perselin, 17α-allylestr-4-en-17β-ol, 3-deketo-17α-allyl-19-nortestosterone
Allylestrenol, sold under the brand names Gestanin and Turinal among others, is a progestin medication which is used to treat recurrent and threatened miscarriage and to prevent premature labor in pregnant women. However, except in the case of proven progesterone deficiency, its use for such purposes is no longer recommended. A Cochrane review in 2025 found that it had little to no effect in subsequent pregnancy outcomes for women with unexplained, recurrent miscarriage. It is also used in Japan to treat benign prostatic hyperplasia (BPH) in men. The medication is used alone and is not formula
Research
170 papers- Evaluation of allylestrenol for clinical pregnancies in patients treated with assisted reproductive techniques: a retrospective, propensity score matched, observational study.BMC pregnancy and childbirth · 2023
- Effects of allylestrenol on hormone levels and delivery outcomes in threatened abortion.American journal of translational research · 2024
- Use of oral allylestrenol in women with recurrent spontaneous abortion: A retrospective clinical trial.Global health & medicine · 2024
- Allylestrenol: a new oral progestogen.Lancet (London, England) · 1961
- Efficacy of allylestrenol combined with ritodrine on threatened premature labor and its influence on inflammatory factors in peripheral blood.Experimental and therapeutic medicine · 2020
via PubMed
Wikidata facts
- Mass
- 300.245
Show 6 more facts
- chemical formula
- C₂₁H₃₂O
- canonical SMILES
- CC12CCC3C(C1CCC2(CC=C)O)CCC4=CCCCC34
- isomeric SMILES
- C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(CC=C)O)CCC4=CCCC[C@H]34
- defined daily dose
- 10
- MCN code
- 3003.39.34
- Commons category
- Allylestrenol
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Article
17 sectionsContents
- Medical uses
- Available forms
- Side effects
- Pharmacology
- Pharmacodynamics
- Progestogenic and off-target activities
- Antigonadotropic effects
- Other activities
- Pharmacokinetics
- Chemistry
- Synthesis
- History
- Society and culture
- Generic names
- Brand names
- Availability
- References
Allylestrenol, sold under the brand names Gestanin and Turinal among others, is a progestin medication which is used to treat recurrent and threatened miscarriage and to prevent premature labor in pregnant women. However, except in the case of proven progesterone deficiency, its use for such purposes is no longer recommended. A Cochrane review in 2025 found that it had little to no effect in subsequent pregnancy outcomes for women with unexplained, recurrent miscarriage. It is also used in Japan to treat benign prostatic hyperplasia (BPH) in men. The medication is used alone and is not formulated in combination with an estrogen. It is taken by mouth.
Side effects of allylestrenol are few and have not been well-defined, but are assumed to be similar to those of related medications. Allylestrenol is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has no other important hormonal activity. The medication is a prodrug of 17α-allyl-19-nortestosterone (3-ketoallylestrenol) in the body.
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