File:Amyloidosis_cutis_dyschromica.png · Wikimedia Commons · See Wikimedia Commons
amyloidosis
Sign in to saveAlso known as amyloid disease, AMYLOID, Amyloidoses
Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. There are several non-specific and vague signs and symptoms associated with amyloidosis. These include fatigue, peripheral edema, weight loss, shortness of breath, palpitations, and feeling faint with standing.
Key facts
- Medical condition.name
- Amyloidosis
- Medical condition.image
- Amyloidosis symptoms from Amyloidosis Support Groups.png
- Medical condition.image_size
- 230px
- Medical condition.caption
- Amyloidosis symptoms are often vague and require different physician specialists for diagnosis. Telltale symptoms may include an enlarged tongue (macroglossia) or bruising around the eyes (purpura)
- Medical condition.field
- Internal medicine
- Medical condition.symptoms
- Feeling tired, weight loss, swelling of the legs, shortness of breath, bleeding, feeling light headed with standing
- Medical condition.onset
- 55–65 years old
- Medical condition.causes
- Genetic or acquired
- Medical condition.diagnosis
- Tissue biopsy
- Medical condition.treatment
- Supportive care, directed at the underlying cause, dialysis, organ transplantation
- Medical condition.prognosis
- Improved with treatment
- Medical condition.frequency
- 3–13 per million per year (AL amyloidosis)
- Medical condition.deaths
- 1 per 1,000 people (developed world)
via Wikipedia infobox
Research
43,400 papers- Systemic amyloidosis.Lancet (London, England) · 2016
- Renal amyloidosis: a new time for a complete diagnosis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2022
- AL (Light-Chain) Cardiac Amyloidosis: A Review of Diagnosis and Therapy.Journal of the American College of Cardiology · 2016
- 2024 Update on Classification, Etiology, and Typing of Renal Amyloidosis: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
- Carpal Tunnel Syndrome: A Potential Early, Red-Flag Sign of Amyloidosis.The Journal of hand surgery · 2019
via PubMed
~28 min read
Encyclopedic overview
20 sectionsContents
- Signs and symptoms
- Kidneys
- Heart
- Nervous system
- Gastrointestinal and accessory organs
- Glands
- Musculoskeletal system
- Eyes
- Oral cavity
- Pathogenesis
- Diagnosis
- Classification
- Alternative
- Treatment
- Support groups
- Prognosis
- Epidemiology
- Research
- See also
- References
Amyloidosis is a group of diseases in which abnormal proteins, known as amyloid fibrils, build up in tissue. There are several non-specific and vague signs and symptoms associated with amyloidosis. These include fatigue, peripheral edema, weight loss, shortness of breath, palpitations, and feeling faint with standing.
In AL amyloidosis, specific indicators can include enlargement of the tongue and periorbital purpura. In wild-type ATTR amyloidosis, non-cardiac symptoms include: bilateral carpal tunnel syndrome, lumbar spinal stenosis, biceps tendon rupture, small fiber neuropathy, and autonomic dysfunction.
Excerpted from Wikipedia’s “amyloidosis” article, available under the CC BY-SA 4.0 licence.