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GeneQ18034276· pop 5· linked from 7 articles

ARHGEF6

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Also known as COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX, Rac/Cdc42 guanine nucleotide exchange factor 6

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

Gene data

ARHGEF6
Name
Rac/Cdc42 guanine nucleotide exchange factor 6
Type
protein-coding
Chromosome
X
Position
136,665,547–136,781,688 (−)
Aliases
COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX
Ensembl
ENSG00000129675
RefSeq RNA
NM_001306177.2, NM_001440993.1, NM_001440994.1, NM_001440995.1, NM_001440996.1
RefSeq protein
NP_001293106.1, NP_001427922.1, NP_001427923.1, NP_001427924.1, NP_001427925.1

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008].

Gene Ontology

Pathways

Regulation of actin cytoskeleton - Homo sapiens (human)Pancreatic cancer - Homo sapiens (human)Cell-Cell communicationSignal TransductionNRAGE signals death through JNKp75 NTR receptor-mediated signallingSignaling by Rho GTPasesCell death signalling via NRAGE, NRIF and NADESignaling by GPCRGPCR downstream signalling

via MyGene.info

Gene · Ensembl

Rac/Cdc42 guanine nucleotide exchange factor 6

Symbol
ARHGEF6
Biotype
Protein coding
Organism
Homo sapiens
Location
Chr X:136,665,547-136,781,688
Strand
Reverse (−)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~3 min read

Encyclopedic overview

6 sections
Contents
  • Domains and functions
  • Interactions
  • See also
  • References
  • External links
  • Further reading

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.

ARHGEF6 is commonly known as the p21-activated protein kinase exchange factor alpha (alpha-PIX or αPIX), because it was identified by binding to p21-activated kinase (PAK) and also contains a guanine nucleotide exchange factor domain.

Excerpted from Wikipedia’s “ARHGEF6” article, available under the CC BY-SA 4.0 licence.

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