AXIN2

Also known as AXIL, ODCRCS, axin 2

Axin-2, also known as axin-like protein (Axil), axis inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is encoded by the AXIN2 gene.

Gene data

AXIN2

Name: axin 2
Type: protein-coding
Position: 65,528,561–65,562,067 (−)
Aliases: AXIL, ODCRCS
Ensembl: ENSG00000168646
RefSeq RNA: NM_001363813.1, NM_004655.4, XM_011525319.3, XM_011525320.2, XM_011525321.3
RefSeq protein: NP_001350742.1, NP_004646.3, XP_011523621.1, XP_011523622.1, XP_011523623.1

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

Article

6 sections

Contents

Function
Clinical significance
Interactions
Further reading
References
External links

Axin-2, also known as axin-like protein (Axil), axis inhibition protein 2 (AXIN2), or conductin, is a protein that in humans is encoded by the AXIN2 gene.

== Function ==