AZGP1

Also known as ZA2G, ZAG, alpha-2-glycoprotein 1, zinc-binding

Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1 gene. AZGP1, also referred to as zinc-alpha-2-glycoprotein (ZAG), is a glycoprotein with a molecular weight of 38-40 kDa. In 1961, AZGP1 was initially isolated from normal human plasma and named as ZAG due to its distinctive electrophoretic mobility within the alpha-2 region and its ability to bind to zinc. Subsequent analysis further identified its specific location on a particular chromosome on chromosome 7q22.1 by fluorescence in situ hybridization. AZGP1 is widely expressed in various tissues and body fluids, inc

Gene data

AZGP1

Name: alpha-2-glycoprotein 1, zinc-binding
Type: protein-coding
Position: 99,966,720–99,976,066 (−)
Aliases: ZA2G, ZAG
Ensembl: ENSG00000160862
RefSeq RNA: NM_001185.4, XM_054358657.1, XM_054358658.1
RefSeq protein: NP_001176.1, XP_054214632.1, XP_054214633.1

Involved in cell adhesion and detection of chemical stimulus involved in sensory perception of bitter taste. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

detection of chemical stimulus involved in sensory perception of bitter taste positive regulation of T cell mediated cytotoxicity antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent immune response cell adhesion negative regulation of cell population proliferation protein transmembrane transport

Molecular function

RNA nuclease activity protein binding transmembrane protein transporter activity

Cellular component

extracellular region extracellular region extracellular region extracellular region extracellular region extracellular region nucleus external side of plasma membrane

Pathways

Transport of small molecules Miscellaneous transport and binding events

via MyGene.info

Gene · Ensembl

alpha-2-glycoprotein 1, zinc-binding

Symbol: AZGP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:99,966,720-99,976,074
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein AZGP1 PDB 1t7v.png

Show 5 more facts

HomoloGene ID: 915
exact match: identifiers.org/ncbigene/563
genomic end: 99976042
genomic start: 99564343
cytogenetic location: 7q22.1

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This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lung epithelium. In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain. Decreased circulating AZGP1 levels are associated with diabetes 2.