AZIN1

Name

antizyme inhibitor 1

Type

protein-coding

Position

102,823,965–102,893,864 (−)

Aliases

AZI, AZI1, AZIA1, OAZI, OAZIN, ODC1L

Ensembl

ENSG00000155096

RefSeq RNA

NM_001301668.3, NM_001363010.1, NM_001363011.1, NM_001363012.1, NM_001363013.1

RefSeq protein

NP_001288597.1, NP_001349939.1, NP_001349940.1, NP_001349941.1, NP_001349942.1

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014].

via MyGene.info

Gene · Ensembl

antizyme inhibitor 1

Symbol

AZIN1

Biotype

Protein coding

Organism

Homo sapiens

Location

8:102,823,965-102,893,864

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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