BCAS1

Also known as AIBC1, NABC1, breast carcinoma amplified sequence 1, brain enriched myelin associated protein 1, PMES-2

Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene.

Gene data

BCAS1

Name: brain enriched myelin associated protein 1
Type: protein-coding
Position: 53,936,777–54,070,641 (−)
Aliases: AIBC1, NABC1, PMES-2
Ensembl: ENSG00000064787
RefSeq RNA: NM_001316361.3, NM_001323347.2, NM_001366295.2, NM_001366296.2, NM_001366297.2
RefSeq protein: NP_001303290.1, NP_001310276.1, NP_001353224.1, NP_001353225.1, NP_001353226.1

This gene resides in a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, it was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, this gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, this gene is a candidate oncogene. [provided by RefSeq, Apr 2016].

Gene Ontology

Biological process

myelination myelination

Cellular component

cytoplasm cytoplasm extracellular exosome

via MyGene.info

Gene · Ensembl

brain enriched myelin associated protein 1

Symbol: BCAS1
Biotype: Protein coding
Organism: Homo sapiens
Location: 20:53,936,777-54,070,675
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 2714
exact match: identifiers.org/ncbigene/8537
genomic start: 52553316
genomic end: 52687304
cytogenetic location: 20q13.2

Sources (4)

via Wikidata · CC0

~1 min read

Article

3 sections

Contents

References
External links
Further reading

Breast carcinoma-amplified sequence 1 is a protein that in humans is encoded by the BCAS1 gene.

Breast carcinoma amplified sequence 1 (BCAS1) was isolated from a region at 20q13 which is amplified in a variety of tumor types and associated with more aggressive tumor phenotypes. Among the genes identified from this region, BCAS1 was found to be highly expressed in three amplified breast cancer cell lines and in one breast tumor without amplification at 20q13.2. However, the BCAS1 gene is not in the common region of maximal amplification and its expression was not detected in the breast cancer cell line MCF7, in which this region is highly amplified. Although not consistently expressed, BCAS1 is a candidate oncogene. It is predicted to encode a protein of 584 amino acids with no significant homology to other proteins.