BCL2L10

Also known as BCL-B, Boo, Diva, bcl2-L-10, BCL2 like 10

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to BCL2L10, and connects out to Q180686, human chromosome 15 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 15.

Vinony links it to 5 Wikipedia language editions.

Gene data

BCL2L10

Name: BCL2 like 10
Type: protein-coding
Position: 52,109,263–52,112,775 (−)
Aliases: BCL-B, Boo, Diva, bcl2-L-10
Ensembl: ENSG00000137875
RefSeq RNA: NM_001306168.1, NM_020396.4
RefSeq protein: NP_001293097.1, NP_065129.1

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008].

Pathways

Apoptosis Modulation and Signaling Regulation of apoptosis by parathyroid hormone-related protein

via MyGene.info

Gene · Ensembl

BCL2 like 10

Symbol: BCL2L10
Biotype: Protein coding
Organism: Homo sapiens
Location: 15:52,109,263-52,112,775
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 8396
exact match: identifiers.org/ncbigene/10017
genomic end: 52404972
genomic start: 52401460
cytogenetic location: 15q21.2

Sources (4)

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Encyclopedic overview

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Contents

References
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External links

Bcl-2-like protein 10 is a protein that in humans is encoded by the BCL2L10 gene.

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus preventing caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASP9 related apoptotic pathway.

Excerpted from Wikipedia’s “BCL2L10” article, available under the CC BY-SA 4.0 licence.