CARF

Also known as ALS2CR8, NYD-SP24, calcium responsive transcription factor

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein also known as calcium-response factor (CaRF) is a protein that in humans is encoded by the ALS2CR8 gene.

Gene data

CARF

Name: calcium responsive transcription factor
Type: protein-coding
Position: 202,912,214–202,988,263 (+)
Aliases: ALS2CR8, NYD-SP24
Ensembl: ENSG00000138380
RefSeq RNA: NM_001104586.4, NM_001282910.3, NM_001282911.3, NM_001282912.3, NM_001322427.3
RefSeq protein: NP_001098056.1, NP_001269839.1, NP_001269840.1, NP_001269841.1, NP_001309356.1

Enables DNA binding activity and DNA-binding transcription factor activity. Involved in cellular response to potassium ion and positive regulation of transcription from RNA polymerase II promoter in response to calcium ion. Predicted to be located in granular component. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological process

regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II

Article

3 sections

Contents

References
External links
Further reading

Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein also known as calcium-response factor (CaRF) is a protein that in humans is encoded by the ALS2CR8 gene.

Knocking out the Carf (Als2cr8) gene in mice results in learning associated deficits. Furthermore, Carf has been shown to function as a transcription factor that regulates the expression of BDNF.