CAVIN2

Also known as PS-p68, SDR, cavin-2, SDPR, serum deprivation response, caveolae associated protein 2

Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene. Cavin-2 is highly expressed in a variety of human endothelial cells.

Gene data

CAVIN2

Name: caveolae associated protein 2
Type: protein-coding
Aliases: PS-p68, SDPR, SDR, cavin-2

This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009].

via MyGene.info

Gene · Ensembl

caveolae associated protein 2

Symbol: CAVIN2
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:191,834,298-191,847,253
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 3422
exact match: identifiers.org/ncbigene/8436
genomic end: 191847088
genomic start: 191834310
cytogenetic location: 2q32.3

Sources (3)

via Wikidata · CC0

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Article

5 sections

Contents

Function
Secretion
Clinical significance
References
Further reading

Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene. Cavin-2 is highly expressed in a variety of human endothelial cells.

This gene has a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein has also been shown to be a substrate for protein kinase C (PKC) phosphorylation.