Also known as C21orf48, CILD26, FBB18, Kur, chromosome 21 open reading frame 59, C21orf59
Cilia- and flagella-associated protein 298 is a protein encoded by CFAP298 gene. It is of interest in part for its association with various diseases. It has been found in high levels in the bone marrow of patients with a negative prognosis of acute myeloid leukemia and an abnormal karyotype. Male Alzheimer's patients have shown a decrease in expression of CFAP298 in their blood cells. The CFAP298 gene lies within the critical region of Down syndrome. There are no clear paralogs in humans, but the gene has homologues widely conserved among animals, fungi, and algae. thumb|A phylogenetic tree sh
This gene encodes a protein that plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Naturally occuring readthrough transcription occurs from this locus to the downstream t-complex 10 like (TCP10L) gene. [provided by RefSeq, Apr 2017].
via MyGene.info
Cilia- and flagella-associated protein 298 is a protein encoded by CFAP298 gene. It is of interest in part for its association with various diseases. It has been found in high levels in the bone marrow of patients with a negative prognosis of acute myeloid leukemia and an abnormal karyotype. Male Alzheimer's patients have shown a decrease in expression of CFAP298 in their blood cells. The CFAP298 gene lies within the critical region of Down syndrome. There are no clear paralogs in humans, but the gene has homologues widely conserved among animals, fungi, and algae. thumb|A phylogenetic tree showing the wide conservation c21orf59.
==Gene== CFAP298 is a gene found on the 21st chromosome at 21q22.1. A total of thirteen splice variants have been found, but only eleven protein coding ones. The most common form of CFAP298 mRNA has 1427 base pairs broken into seven exons. Its closest neighbors on the chromosome are TCP10L, EVA1C, LOC100506185, OR7E23P, and SYNJ1.
Discovered by embedding cosine similarity (sentence-transformers MiniLM, 384-dim).