cilofungin

Also known as LY-121019, LY121019

Cilofungin (INN) is the first clinically applied member of the echinocandin family of antifungal drugs. It was derived from a fungus in the genus Aspergillus. It accomplishes this by interfering with an invading fungus' ability to synthesize the cell wall (specifically, it inhibits the synthesis of (1→3)-β-D-glucan).

Research

98 papers

Cilofungin (LY121019) shows nonlinear plasma pharmacokinetics and tissue penetration in rabbits.Antimicrobial agents and chemotherapy · 1990
Cilofungin (LY121019) inhibits Candida albicans (1-3)-beta-D-glucan synthase activity.Antimicrobial agents and chemotherapy · 1988
Echinocandin antifungal drugs.Lancet (London, England) · 2003
Use of cilofungin as direct fluorescent probe for monitoring antifungal drug-membrane interaction.Antimicrobial agents and chemotherapy · 1994
In-vitro activity of cilofungin (LY121019) in comparison with amphotericin B.The Journal of antimicrobial chemotherapy · 1989

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Wikidata facts

Mass: 1029.491

Show 5 more facts

chemical formula: C₄₉H₇₁N₇O₁₇
canonical SMILES: CCCCCCCCOC1=CC=C(C=C1)C(=O)NC2CC(C(NC(=O)C3C(C(CN3C(=O)C(NC(=O)C(NC(=O)C4CC(CN4C(=O)C(NC2=O)C(C)O)O)C(C(C5=CC=C(C=C5)O)O)O)C(C)O)C)O)O)O
isomeric SMILES: CCCCCCCCOC1=CC=C(C=C1)C(=O)N[C@H]2C[C@H]([C@H](NC(=O)[C@@H]3[C@H]([C@H](CN3C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]4C[C@H](CN4C(=O)[C@@H](NC2=O)[C@@H](C)O)O)[C@@H]([C@H](C5=CC=C(C=C5)O)O)O)[C@@H](C)O)C)O)O)O
World Health Organisation international non-proprietary name: cilofungin
Commons category: Cilofungin

Sources (1)