caspofungin

Also known as MK-991, 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin b0, (4R,5S)-5-((2-Aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(P-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide, L-743872

Caspofungin (INN; brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc. It is a member of a class of antifungals termed the echinocandins. It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.image: Caspofungin.svg
Drug.image_class: skin-invert-image
Drug.width: 275
Drug.tradename: Cancidas
Drug.MedlinePlus: a615001
Drug.DailyMedID: Caspofungin
Drug.pregnancy_AU: B3
Drug.routes_of_administration: Intravenous
Drug.ATC_prefix: J02
Drug.ATC_suffix: AX04
Drug.legal_AU

Article

10 sections

Contents

Medical uses
Spectrum of activity
Specific populations
Adverse effects
Liver effects
Sensitivity reactions
Pharmacology
Pharmacokinetics
Interactions
References

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