fosfluconazole
Sign in to saveFosfluconazole () is a water-soluble phosphate prodrug of fluconazole — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
In the Vinony graph
Vinony's link graph records 93 inbound references to fosfluconazole, and connects out to antifungal, medication and digital object identifier.
It is catalogued under topics including Chemical pages without DrugBank identifier, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.
Vinony links it to 6 Wikipedia language editions.
Research
44 papers- [Nonclinical studies and clinical studies on fosfluconazole, a triazole antifungal agent (Prodif)].Nihon yakurigaku zasshi. Folia pharmacologica Japonica · 2004
- Fluconazole Population Pharmacokinetics after Fosfluconazole Administration and Dosing Optimization in Extremely Low-Birth-Weight Infants.Microbiology spectrum · 2022
- Fosfluconazole for antifungal prophylaxis in very low birth weight infants.International journal of pediatrics · 2009
- Pharmacokinetics of fosfluconazole and fluconazole following multiple intravenous administration of fosfluconazole in healthy male volunteers.British journal of clinical pharmacology · 2004
- Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients.Journal of clinical pharmacy and therapeutics · 2012
via PubMed
Wikidata facts
- Mass
- 386.07
Show 2 more facts
- chemical formula
- C₁₃H₁₃F₂N₆O₄P
- canonical SMILES
- C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)OP(=O)(O)O
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
1 sectionsContents
- References
{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | ChemSpiderID2 = | verifiedrevid = 447618215 | drug_name = | type = | IUPAC_name = {[2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-yl]oxy}phosphonic acid | image = Fosfluconazol.svg | image_class = skin-invert-image | width = | alt = | caption = | tradename = | Drugs.com = | MedlinePlus = | licence_EU = | licence_US = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration = IV
| bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = 194798-83-9 | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | PubChem = 214356 | DrugBank_Ref = | DrugBank = | ChEMBL_Ref = | ChEMBL = 1908301 | ChemSpiderID_Ref = | ChemSpiderID = 185843 | UNII_Ref = | UNII = 3JIJ299EWH | synonyms = | C=13 | H=13 | F=2 | N=6 | O=4 | P=1 | SMILES = Fc1ccc(c(F)c1)C(OP(=O)(O)O)(Cn2ncnc2)Cn3ncnc3 | StdInChI_Ref = | StdInChI = 1S/C13H13F2N6O4P/c14-10-1-2-11(12(15)3-10)13(25-26(22,23)24,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9H,4-5H2,(H2,22,23,24) | StdInChIKey_Ref = | StdInChIKey = GHJWNRRCRIGGIO-UHFFFAOYSA-N }}
Excerpted from Wikipedia’s “fosfluconazole” article, available under the CC BY-SA 4.0 licence.