cinacalcet
Sign in to saveAlso known as AMG-073, Mimpara®, Sensipar®, CNC, N-((1R)-1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine, (R)-alpha-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine, (R)-alpha-Methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine
Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat primary hyperparathyroidism, tertiary hyperparathyroidism and parathyroid carcinoma. Cinacalcet acts as a calcimimetic (i.e., it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues.
In the Vinony graph
Within Vinony's link graph, cinacalcet is referenced by 35 other articles, and connects out to paresthesia, allosteric regulation and liver.
Vinony files it under 1-Naphthyl compounds, 3-(Trifluoromethyl)phenyl compounds and CYP2D6 inhibitors.
Its subject is documented across 14 Wikipedia language editions.
Research
1,818 papers- Hypocalcemia and cardiovascular mortality in cinacalcet users.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
- Cinacalcet use in secondary hyperparathyroidism: a machine learning-based systematic review.Frontiers in endocrinology · 2023
- Cinacalcet hydrochloride.Drugs · 2005
- Cinacalcet studies in pediatric subjects with secondary hyperparathyroidism receiving dialysis.Pediatric nephrology (Berlin, Germany) · 2020
- Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial.JAMA · 2017
via PubMed
Wikidata facts
- Mass
- 357.17
Show 6 more facts
- chemical formula
- C₂₂H₂₂F₃N
- defined daily dose
- 60
- Commons category
- Cinacalcet
- isomeric SMILES
- C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
- canonical SMILES
- CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
- World Health Organisation international non-proprietary name
- cinacalcet
Sources (6)
via Wikidata · CC0
~4 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Pregnancy and lactation
- Contraindications
- Adverse effects
- Overdose
- Interactions
- Pharmacology
- Mechanism of action
- References
Cinacalcet, sold under the brand name Sensipar among others, is a medication used to treat primary hyperparathyroidism, tertiary hyperparathyroidism and parathyroid carcinoma. Cinacalcet acts as a calcimimetic (i.e., it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues.
The most common side effects include nausea and vomiting.
Excerpted from Wikipedia’s “cinacalcet” article, available under the CC BY-SA 4.0 licence.