CLDN14
Sign in to saveAlso known as DFNB29, claudin 14
Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called claudins.
Gene data
CLDN14- Name
- claudin 14
- Type
- protein-coding
- Aliases
- DFNB29
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010].
via MyGene.info
Gene · Ensembl
claudin 14
- Symbol
- CLDN14
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 21:36,460,616-36,576,569
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 8115
- exact match
- identifiers.org/ncbigene/23562
- genomic end
- 37948867
- genomic start
- 37832919
- cytogenetic location
- 21q22.13
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- See also
- References
- External links
- Further reading
Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called claudins.
The protein encoded by CLDN14 is an integral membrane protein and a component of tight junctions, one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets. Tight junctions form continuous seals around cells and serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space.