Gene data
CMA1- Name
- chymase 1
- Type
- protein-coding
- Position
- 24,505,353–24,508,271 (−)
- Aliases
- CYH, MCT1, chymase
- Ensembl
- ENSG00000092009
- RefSeq RNA
- NM_001308083.2, NM_001836.5
- RefSeq protein
- NP_001295012.1, NP_001827.1
This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015].
Gene Ontology
Biological process
Molecular function
Pathways
Renin-angiotensin system - Homo sapiens (human)Diabetic cardiomyopathy - Homo sapiens (human)Signaling by SCF-KITDegradation of the extracellular matrixExtracellular matrix organizationActivation of Matrix MetalloproteinasesSignal TransductionMetabolism of Angiotensinogen to AngiotensinsPeptide hormone metabolismMetabolism of proteins
via MyGene.info
Gene · Ensembl
chymase 1
- Symbol
- CMA1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:24,505,353-24,508,271
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein CMA1 PDB 1klt.png
Show 7 more facts
- HomoloGene ID
- 55606
- genomic end
- 24977471
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/1215
- chromosome
- human chromosome 14
- genomic start
- 24974559
- cytogenetic location
- 14q12
Sources (4)
via Wikidata · CC0