Structure via PubChem · Public domain (PubChem)
cobicistat
Sign in to saveAlso known as GS-9350, GS 9350, 1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate
Cobicistat, sold under the brand name Tybost, is a medication for use in the treatment of human immunodeficiency virus infection (HIV/AIDS). Its major mechanism of action is through the inhibition of human CYP3A proteins.
Chemical data
- Formula
- C40H53N7O5S2
- Molecular weight
- 776 g/mol
- IUPAC name
- 1,3-thiazol-5-ylmethyl N-[(2R,5R)-5-[[(2S)-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]-4-morpholin-4-ylbutanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
- SMILES
- CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5
- InChIKey
- ZCIGNRJZKPOIKD-CQXVEOKZSA-N
- XLogP
- 5.7
- Polar surface area
- 195 Ų
- H-bond donors
- 3
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Research
829 papers- PMID 272272122015
- Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide: A Review in HIV-1 Infection.Drugs · 2018
- Cobicistat Versus Ritonavir: Similar Pharmacokinetic Enhancers But Some Important Differences.The Annals of pharmacotherapy · 2017
- Cobicistat: Review of a Pharmacokinetic Enhancer for HIV Infection.Clinical therapeutics · 2015
- Cobicistat: A case of mislabelled drug-drug interaction risk?British journal of clinical pharmacology · 2020
via PubMed
~6 min read
Encyclopedic overview
4 sectionsContents
- Chemistry
- Synthesis
- Discovery and development
- References
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| pronounce = | tradename = Tybost | Drugs.com = | MedlinePlus = a616029 | licence_EU = yes | licence_US = | DailyMedID = Cobicistat | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Rx-only | legal_status = | dependency_liability = | routes_of_administration = | ATC_prefix = V03 | ATC_suffix = AX03 | ATC_supplemental =
Excerpted from Wikipedia’s “cobicistat” article, available under the CC BY-SA 4.0 licence.