corydaline

Also known as (13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline, (+)-Corydaline

Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.

Research

91 papers

Corydaline alleviates Parkinson's disease by regulating autophagy and GSK-3β phosphorylation.Psychopharmacology · 2024
Corydaline binds to a druggable pocket of hEAG1 channel and inhibits hepatic carcinoma cell viability.European journal of pharmacology · 2024
Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression.Journal of Asian natural products research · 2017
Corydaline attenuates osteolysis in rheumatoid arthritis via mitigating reactive oxygen species production and suppressing calcineurin-Nfatc1 signaling.International immunopharmacology · 2024
Corydaline and l-tetrahydropalmatine attenuate morphine-induced conditioned place preference and the changes in dopamine D(2) and GluA1 AMPA receptor expression in rats.European journal of pharmacology · 2020

via PubMed

Wikidata facts

Mass: 369.194

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chemical formula: C₂₂H₂₇NO₄
isomeric SMILES: C[C@@H]1[C@@H]2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
canonical SMILES: CC1C2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC

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Corydaline is an acetylcholinesterase inhibitor isolated from Corydalis yanhusuo.

Corydaline is a pharmacologically active isoquinoline alkaloid isolated from Corydalis tubers. It also has diverse biological activities. It exhibits the antiacetylcholinesterase(AChE; IC50 = 15 μM), antiallergic, antinociceptive, and gastric emptying activities.