Structure via PubChem · Public domain (PubChem)
کومافوس
Sign in to saveAlso known as Coumafos, O-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yl) O,O-diethyl thiophosphate, 3-Chloro-4-methyl-7-coumarinyl diethyl phosphorothioate, 3-Chloro-4-methyl-7-hydroxycoumarin diethyl thiophosphoric acid ester, 3-Chloro-7-diethoxyphosphinothioyloxy-4-methylcoumarin, 3-Chloro-7-hydroxy-4-methyl-coumarin O,O-diethyl phosphorothioate, O,O-Diethyl 3-chloro-4-methyl-7-umbelliferone thiophosphate, O,O-Diethyl O-(3-chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl)phosphorothioate
Coumaphos is a nonvolatile, fat-soluble phosphorothioate with ectoparasiticide properties: it kills insects and mites. It is well known by a variety of brand names as a dip or wash, used on farm and domestic animals to control ticks, mites, flies and fleas.
Chemical data
- Formula
- C14H16ClO5PS
- Molecular weight
- 362.8 g/mol
- IUPAC name
- 3-chloro-7-diethoxyphosphinothioyloxy-4-methylchromen-2-one
- SMILES
- CCOP(=S)(OCC)OC1=CC2=C(C=C1)C(=C(C(=O)O2)Cl)C
- InChIKey
- BXNANOICGRISHX-UHFFFAOYSA-N
- XLogP
- 4.5
- Polar surface area
- 86.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
486 papers- Toxicity of Coumaphos Residues in Beeswax Foundation to the Honey Bee Brood.Environmental toxicology and chemistry · 2023
- Coumaphos residue transfer to honey bee brood (Apis mellifera) in realistic scenarios.Research in veterinary science · 2023
- Anthelmintics.Veterinary parasitology · 1993
- Unveiling Molecular Mechanisms Mediating Coumaphos Tolerance in Western Honey Bees (Apis mellifera).Journal of agricultural and food chemistry · 2025
- Simple and Fast Pesticide Nanosensors: Example of Surface Plasmon Resonance Coumaphos Nanosensor.Micromachines · 2023
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 362.014
- Has use
- insecticide
Show 4 more facts
- chemical formula
- C₁₄H₁₆ClO₅PS
- canonical SMILES
- CCOP(=S)(OCC)OC1=CC2=C(C=C1)C(=C(C(=O)O2)Cl)C
- subject has role
- acetylcholinesterase inhibitor
- Commons category
- Coumaphos
via Wikidata · CC0