Structure via PubChem · Public domain (PubChem)
dantrolene
Sign in to saveAlso known as Dantrium®, F-368, F-440, Ryanodex®, Dantrolene sodium, Dantrium, Dantamacrin, Dantrolen
thumb|250px|The sodium salt of dantrolene (shown) is an orange crystalline solid.
In the Vinony graph
Within Vinony's link graph, dantrolene is referenced by 101 other articles, and connects out to neuromuscular-blocking drug, vecuronium bromide and metocurine chloride.
It is catalogued under topics including 4-Nitrophenyl compounds, Chemical substances for emergency medicine and Drugboxes which contain changes to verified fields.
Its subject is documented across 21 Wikipedia language editions.
Key facts
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 459436942
- Drug.image
- Dantrolene.svg
- Drug.image_class
- skin-invert-image
- Drug.alt
- Structural formula of dantrolene
- Drug.width
- 250
- Drug.image2
- Dantrolene 3D spacefill.png
- Drug.image_class2
- bg-transparent
- Drug.alt2
- Space-filling model of the dantrolene molecule
- Drug.tradename
- Dantrium, Revonto, Ryanodex
- Drug.MedlinePlus
- a682576
- Drug.DailyMedID
- Dantrolene
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- By mouth, intravenous
- Drug.ATC_prefix
- M03
- Drug.ATC_suffix
- CA01
- Drug.legal_CA
- Rx-only
- Drug.legal_UK
- POM
via Wikipedia infobox
Chemical data
- Formula
- C14H10N4O5
- Molecular weight
- 314.25 g/mol
- IUPAC name
- 1-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione
- SMILES
- C1C(=O)NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]
- InChIKey
- OZOMQRBLCMDCEG-UHFFFAOYSA-N
- XLogP
- 1.7
- Polar surface area
- 121 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
3,353 papers- Dantrolene.Canadian Anaesthetists' Society journal · 1984
- [Dantrolene. Pharmacological and therapeutic aspects].Der Anaesthesist · 2003
- Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2020
- Approaches to Optimizing Dantrolene Neuroprotection for the Treatment of Alzheimer's Disease.Current Alzheimer research · 2020
- Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review.CJEM · 2010
via PubMed
Wikidata facts
- Mass
- 314.065119
Show 4 more facts
- chemical formula
- C₁₄H₁₀N₄O₅
- canonical SMILES
- C1C(=O)NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]
- defined daily dose
- 0.1
- Commons category
- Dantrolene
via Wikidata · CC0
~8 min read
Encyclopedic overview
10 sectionsContents
- Contraindications
- Pregnancy and breastfeeding
- Interactions
- Pharmacology
- Chemistry
- Synthesis
- History
- Society and culture
- Legal status
- References
{{Infobox drug | Verifiedfields = changed | verifiedrevid = 459436942 | image = Dantrolene.svg | image_class = skin-invert-image | alt = Structural formula of dantrolene | width = 250 | image2 = Dantrolene 3D spacefill.png | image_class2 = bg-transparent | alt2 = Space-filling model of the dantrolene molecule
| tradename = Dantrium, Revonto, Ryanodex | Drugs.com = | MedlinePlus = a682576 | DailyMedID = Dantrolene | pregnancy_AU = B2 | pregnancy_AU_comment = | routes_of_administration = By mouth, intravenous | ATC_prefix = M03 | ATC_suffix = CA01 | ATC_supplemental =
Excerpted from Wikipedia’s “dantrolene” article, available under the CC BY-SA 4.0 licence.