Structure via PubChem · Public domain (PubChem)
methocarbamol
Sign in to saveAlso known as Robaxin®, Metocarbamolo, Méthocarbamol, Methocarbamolum, Metocarbamol, Delaxin, (RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate
Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain. It may be used together with rest, physical therapy, and pain medication. It has limited use for rheumatoid arthritis and cerebral palsy. Effects generally begin within half an hour. It is taken by mouth or injection into a vein.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 457287029
- Drug.image
- Methocarbamol.svg
- Drug.image_class
- skin-invert-image
- Drug.tradename
- Robaxin, Marbaxin, others
- Drug.MedlinePlus
- a682579
- Drug.DailyMedID
- Methocarbamol
- Drug.pregnancy_AU
- B2
- Drug.routes_of_administration
- By mouth, intravenous
- Drug.ATC_prefix
- M03
- Drug.ATC_suffix
- BA03
- Drug.legal_CA
- OTC
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.metabolism
- Liver
- Drug.elimination_half life
- 1.14–1.24 hours
- Drug.CAS_number
- 532-03-6
via Wikipedia infobox
Chemical data
- Formula
- C11H15NO5
- Molecular weight
- 241.24 g/mol
- IUPAC name
- [2-hydroxy-3-(2-methoxyphenoxy)propyl] carbamate
- SMILES
- COC1=CC=CC=C1OCC(COC(=O)N)O
- InChIKey
- GNXFOGHNGIVQEH-UHFFFAOYSA-N
- XLogP
- 0.6
- Polar surface area
- 91 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
372 papers- Methocarbamol.2006
- Methocarbamol.2012
- Commentary: Is Polyethylene Glycol Toxicity From Intravenous Methocarbamol Fact or Fiction?Journal of pain & palliative care pharmacotherapy · 2024
- Methocarbamol.2026
- Association Between Postoperative Methocarbamol and Postoperative Pain Opioid Dose Requirements: A Retrospective Cohort Study.The Clinical journal of pain · 2023
via PubMed
~10 min read
Encyclopedic overview
18 sectionsContents
- Medical use
- Comparison to similar agents
- Contraindications
- Side effects
- Elderly
- Pregnancy
- Overdose
- Abuse
- Interactions
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Metabolism
- Society and culture
- Economics
- Marketing
- Research
- References
Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain. It may be used together with rest, physical therapy, and pain medication. It has limited use for rheumatoid arthritis and cerebral palsy. Effects generally begin within half an hour. It is taken by mouth or injection into a vein.
Common side effects include headaches, sleepiness, and dizziness. Serious side effects may include anaphylaxis, liver problems, confusion, and seizures. Use is not recommended in pregnancy and breastfeeding. Because of the risk of injury, skeletal muscle relaxants should generally be avoided in geriatric patients. Methocarbamol is a centrally acting muscle relaxant. How it works is unclear, but it does not appear to affect muscles directly.
Excerpted from Wikipedia’s “methocarbamol” article, available under the CC BY-SA 4.0 licence.