degranulation
Sign in to saveAlso known as cell degranulation
thumb|300px|right|The degranulation process in a Mast cell. 1 = antigen; 2 = [[IgE; 3 = FcεR1; 4 = preformed mediators (histamine, proteases, chemokines, heparin); 5 = granules; 6 - Mast cell; 7 - newly formed mediators (prostaglandins, leukotrienes, thromboxanes, platelet-activating factor)]] Degranulation is a cellular process that releases antimicrobial, cytotoxic, or other molecules from secretory vesicles called granules found inside some cells. It is used by several different cells involved in the immune system, including granulocytes (neutrophils, basophils, eosinophils, and mast cells)
Research
21,108 papers- Neutrophil-like cells derived from the HL-60 cell-line as a genetically-tractable model for neutrophil degranulation.PloS one · 2024
- Immune Cell Degranulation in Fungal Host Defence.Journal of fungi (Basel, Switzerland) · 2021
- Neuronal substance P-driven MRGPRX2-dependent mast cell degranulation products differentially promote vascular permeability.Frontiers in immunology · 2024
- Eosinophilic esophagitis: absolute eosinophilic count, peak eosinophilic count, and potential biomarkers of eosinophilic degranulation products-an in-depth systematic review.Translational pediatrics · 2024
- Novel reactivation and degranulation of mast cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
via PubMed
~3 min read
Article
7 sectionsContents
- Mast cells
- Eosinophils
- Neutrophils
- Cytotoxic T cells and NK cells
- See also
- References
- External links
thumb|300px|right|The degranulation process in a Mast cell. 1 = antigen; 2 = [[IgE; 3 = FcεR1; 4 = preformed mediators (histamine, proteases, chemokines, heparin); 5 = granules; 6 - Mast cell; 7 - newly formed mediators (prostaglandins, leukotrienes, thromboxanes, platelet-activating factor)]] Degranulation is a cellular process that releases antimicrobial, cytotoxic, or other molecules from secretory vesicles called granules found inside some cells. It is used by several different cells involved in the immune system, including granulocytes (neutrophils, basophils, eosinophils, and mast cells). It is also used by certain lymphocytes such as natural killer (NK) cells and cytotoxic T cells, whose main purpose is to destroy invading microorganisms.
==Mast cells== Degranulation in mast cells is part of an inflammatory response, and substances such as histamine are released. Granules from mast cells mediate processes such as "vasodilation, vascular homeostasis, innate and adaptive immune responses, angiogenesis, and venom detoxification."