DHX58
Sign in to saveAlso known as D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58
Probable ATP-dependent RNA helicase DHX58 also known as RIG-I-like receptor 3 (RLR-3) or RIG-I-like receptor LGP2 (RLR) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the DHX58 gene. The protein encoded by the gene DHX58 is known as LGP2 (Laboratory of Genetics and Physiology 2).
Gene data
DHX58- Name
- DExH-box helicase 58
- Type
- protein-coding
- Aliases
- D11LGP2, D11lgp2e, LGP2, RLR-3
Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
via MyGene.info
Gene · Ensembl
DExH-box helicase 58
- Symbol
- DHX58
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:42,101,404-42,112,735
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein DHX58 PDB 2RQA.png
Show 8 more facts
- HomoloGene ID
- 69371
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/79132
- chromosome
- human chromosome 17
- genomic start
- 40253422
- genomic end
- 42112714
- cytogenetic location
- 17q21.2
- expressed in
- tibial nerve
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
3 sectionsContents
- Structure and function
- References
- Further reading
Probable ATP-dependent RNA helicase DHX58 also known as RIG-I-like receptor 3 (RLR-3) or RIG-I-like receptor LGP2 (RLR) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the DHX58 gene. The protein encoded by the gene DHX58 is known as LGP2 (Laboratory of Genetics and Physiology 2).
== Structure and function ==
Excerpted from Wikipedia’s “DHX58” article, available under the CC BY-SA 4.0 licence.