Structure via PubChem · Public domain (PubChem)
difenoxin
Sign in to saveAlso known as difenoxin hydrochloride, MCN-JR-15,403-11, Motofen®, R-15403, diphenoxilic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid, diphenoxylic acid, Diphenoxilic acid
Difenoxin (Motofen, R-15403) is an opioid drug used, often in combination with atropine, to treat diarrhea. It is the principal metabolite of diphenoxylate.
Chemical data
- Formula
- C28H28N2O2
- Molecular weight
- 424.5 g/mol
- IUPAC name
- 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1978
- Admin. routes
- oral
via ChEMBL · EBI
~4 min read
Encyclopedic overview
5 sectionsContents
- Available forms
- Side effects
- Mechanism of action
- Legal status
- References
Difenoxin (Motofen, R-15403) is an opioid drug used, often in combination with atropine, to treat diarrhea. It is the principal metabolite of diphenoxylate.
It was first approved in the US in 1978 and in 1980 in the former West Germany.
Excerpted from Wikipedia’s “difenoxin” article, available under the CC BY-SA 4.0 licence.