difenoxin

Also known as difenoxin hydrochloride, MCN-JR-15,403-11, Motofen®, R-15403, diphenoxilic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid, diphenoxylic acid, Diphenoxilic acid

Difenoxin (Motofen, R-15403) is an opioid drug used, often in combination with atropine, to treat diarrhea. It is the principal metabolite of diphenoxylate.

Chemical data

Formula: C28H28N2O2
Molecular weight: 424.5 g/mol
IUPAC name: 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylic acid

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1978
Admin. routes: oral

via ChEMBL · EBI

Wikidata facts

Mass: 424.215

Show 4 more facts

chemical formula: C₂₈H₂₈N₂O₂
canonical SMILES: C1CN(CCC1(C2=CC=CC=C2)C(=O)O)CCC(C#N)(C3=CC=CC=C3)C4=CC=CC=C4
World Health Organisation international non-proprietary name: difenoxin
Commons category: Difenoxin

Sources (2)

via Wikidata · CC0

~4 min read

Article

5 sections

Contents

Available forms
Side effects
Mechanism of action
Legal status
References

Difenoxin (Motofen, R-15403) is an opioid drug used, often in combination with atropine, to treat diarrhea. It is the principal metabolite of diphenoxylate.

It was first approved in the US in 1978 and in 1980 in the former West Germany.