File:Prednisolone-2D-skeletal.svg · Wikimedia Commons · See Wikimedia Commons
prednisolone
Sign in to saveAlso known as DELTA.1-Cortisol, Orapred®, Pediapred®, 1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione, 1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol, 3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene, metacortandralone, Delta(1)-dehydrocortisol
alt=3D space-filling model of Prednisolone under physiological conditions (pH 7.4) and in ALPB solvent Wetoctanol.|thumb|3D space-filling model of prednisolone under physiological conditions (pH 7.4) and in a solvent model
OverviewAI-generated
Prednisolone is a chemical compound with the formula C₂₁H₂₈O₅. Its molecular mass is listed as 360.194, while its weight is recorded as 360.4. The compound has a defined daily dose of 10.
Chemical properties include an xlogp value of 1.6 and a topological polar surface area of 94.8. The molecule contains three hydrogen bond donors and five hydrogen bond acceptors, with a charge of 0.
Prednisolone is referenced by 818 other encyclopedia articles. A search for the term yields a count of 73175 entries in the PubMed database.
Synthesized by Vinony from 19 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.
Key facts
- Drug.image
- Prednisolone-2D-skeletal.svg
- Drug.image_class
- skin-invert-image
- Drug.image2
- Prednisolone-from-xtal-3D-bs-17.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Sterane, others
- Drug.MedlinePlus
- a615042
- Drug.DailyMedID
- Prednisolone
- Drug.pregnancy_AU
- A
- Drug.routes_of_administration
- By mouth, intravenous, topical, ophthalmic
- Drug.class
- Glucocorticoid
- Drug.ATC_prefix
- A07
- Drug.ATC_suffix
- EA01
- Drug.ATC_supplemental
- , , , , , , , , , , , , , , , , , , ,
- Drug.legal_UK
- POM
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.elimination_half life
- 2–3.5 hours
- Drug.excretion
- urine
via Wikipedia infobox
Chemical data
- Formula
- C21H28O5
- Molecular weight
- 360.4 g/mol
- IUPAC name
- (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
- SMILES
- C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O
- InChIKey
- OIGNJSKKLXVSLS-VWUMJDOOSA-N
- XLogP
- 1.6
- Polar surface area
- 94.8 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
73,175 papers- Prednisolone.Journal of the American Pharmaceutical Association · 1976
- PREDNISOLONE acetate.Journal of the American Medical Association · 1958
- The bioavailability and therapeutic effectiveness of prednisolone acetate vs. prednisolone sodium phosphate: a 20-year review.The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, Inc · 1991
- [Study on the colon specific delivery of prednisolone using chitosan capsules].Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan · 2007
- PREDNISOLONE butylacetate.Journal of the American Medical Association · 1958
via PubMed
Wikidata facts
- Subclass of
- steroid
- Has part
- oxygen
- Mass
- 360.194
- Has use
- medication
Show 11 more facts
- chemical formula
- C₂₁H₂₈O₅
- Commons category
- Prednisolone
- isomeric SMILES
- C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1CC[C@@]2(C(=O)CO)O)CCC4=CC(=O)C=C[C@]34C)O
- canonical SMILES
- CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O
- World Health Organisation international non-proprietary name
- prednisolone
- subject has role
- essential medicine
- different from
- prednisone
- has characteristic
- bitterness
- stylized name
- prednisoLONE
- defined daily dose
- 10
- side effect
- depression
Sources (9)
via Wikidata · CC0
~15 min read
Encyclopedic overview
21 sectionsContents
- Medical uses
- Systemic use
- Topical use
- Adverse effects
- Pregnancy and breastfeeding
- Local adverse effects in the eye
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Prednisone
- Chemistry
- Interactions
- Special populations
- Children
- Pregnancy and breastfeeding
- Society and culture
- Dosage forms
- Athletics
- Veterinary uses
- References
- External links
alt=3D space-filling model of Prednisolone under physiological conditions (pH 7.4) and in ALPB solvent Wetoctanol.|thumb|3D space-filling model of prednisolone under physiological conditions (pH 7.4) and in a solvent model
Prednisolone is a corticosteroid, a steroid hormone used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers, electrolyte imbalances, and skin conditions. Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma, multiple sclerosis, and phimosis. It can be taken by mouth, injected into a vein, used topically as a skin cream, or as eye drops.
Excerpted from Wikipedia’s “prednisolone” article, available under the CC BY-SA 4.0 licence.