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Depression is a mental health condition in which a person experiences a persistent low mood and loses interest in activities they normally enjoy. It matters because it can significantly affect a person's daily functioning, relationships, and overall quality of life.
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Research
730,363 papers- Major Depression and Its Recurrences: Life Course Matters.ReviewAnnual review of clinical psychology · 2022Monroe SM, Harkness KLDOI: 10.1146/annurev-clinpsy-072220-021440
- Depression.ReviewPrimary care · 1999Rakel REDOI: 10.1016/s0095-4543(08)70003-4
- Depression's Problem With Men.AMA journal of ethics · 2021Swetlitz NDOI: 10.1001/amajethics.2021.586
- Inflammation: depression fans the flames and feasts on the heat.ReviewThe American journal of psychiatry · 2015Kiecolt-Glaser JK, Derry HM, Fagundes CPDOI: 10.1176/appi.ajp.2015.15020152
- The PHQ-8 as a measure of current depression in the general population.Journal of affective disorders · 2009Kroenke K, Strine TW, Spitzer RL et al.DOI: 10.1016/j.jad.2008.06.026
- [Depression].Nederlands tijdschrift voor geneeskunde · 2025Lucassen P, Spijker J
- Neurobiology of resilience in depression: immune and vascular insights from human and animal studies.ReviewThe European journal of neuroscience · 2021Dudek KA, Dion-Albert L, Kaufmann FN et al.DOI: 10.1111/ejn.14547
- [Depression and schizophrenia].ReviewZhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2003Smulevich AV
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Wikidata facts
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- Noun depression 2686170.svg
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- P8168
- Milium
- Commons category
- Depression (mood)
- ICPC 2 ID
- P76
- NCI Thesaurus ID
- C2982
- exact match
- purl.obolibrary.org/obo/SYMP_0000022
- WordLift URL
- data.thenextweb.com/tnw/entity/mental_depression
- hashtag
- depression
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Article
Depression is a mental state of low mood and aversion to activity. It affects about 3.5% of the global population, or about 280 million people worldwide, as of 2020. Depression affects a person's thoughts, behavior, feelings, and sense of well-being. The pleasure or joy that a person gets from certain experiences is reduced, and the afflicted person often experiences a loss of motivation or interest in those activities. People with depression may experience sadness, feelings of dejection or lack of hope, difficulty in thinking and concentration, hypersomnia or insomnia, overeating or anorexia, or suicidal thoughts.
Depression can have multiple, sometimes overlapping, origins. Depression can be a normal temporary reaction to life events, such as the loss of a loved one. Additionally, depression can be a symptom of some mood disorders, such as major depressive disorder, bipolar disorder, and dysthymia. Depression is also a symptom of some physical diseases and a side effect of some drugs and medical treatments.
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