NPAS3
Sign in to saveAlso known as neuronal PAS domain protein 3, MOP6, PASD6, bHLHe12
NPAS3 or Neuronal PAS domain protein 3 is a brain-enriched transcription factor belonging to the bHLH-PAS superfamily of transcription factors, the members of which carry out diverse functions, including circadian oscillations, neurogenesis, toxin metabolism, hypoxia, and tracheal development. NPAS3 contains a basic helix-loop-helix structural motif and two PAS domain, like the other proteins in the superfamily.
Gene data
NPAS3- Name
- neuronal PAS domain protein 3
- Type
- protein-coding
- Aliases
- MOP6, PASD6, bHLHe12
This gene encodes a member of the basic helix-loop-helix and PAS domain-containing family of transcription factors. The encoded protein is localized to the nucleus and may regulate genes involved in neurogenesis. Chromosomal abnormalities that affect the coding potential of this gene are associated with schizophrenia and cognitive disability. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
via MyGene.info
Gene · Ensembl
neuronal PAS domain protein 3
- Symbol
- NPAS3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 14:32,934,396-33,820,863
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 8461
- exact match
- identifiers.org/ncbigene/64067
- genomic end
- 33820863
- genomic start
- 32934396
- cytogenetic location
- 14q13.1
via Wikidata · CC0
~2 min read
Article
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
NPAS3 or Neuronal PAS domain protein 3 is a brain-enriched transcription factor belonging to the bHLH-PAS superfamily of transcription factors, the members of which carry out diverse functions, including circadian oscillations, neurogenesis, toxin metabolism, hypoxia, and tracheal development. NPAS3 contains a basic helix-loop-helix structural motif and two PAS domain, like the other proteins in the superfamily.
It functions as an heterodimer by binding ARNT2, another member of the bHLH-PAS superfamily.