Also known as 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-dichlororibofuranosylbenzimidazole, dichlororibofuranosylbenzimidazole, 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole
5,6-Dichloro-1-β--ribofuranosylbenzimidazole (DRB) is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF), and positive transcription elongation factor b (P-TEFb). DRB is a nucleoside analog and also inhibits some protein kinases.
Wikidata facts
- Mass
- 318.017
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- Commons category
- 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole
- chemical formula
- C₁₂H₁₂Cl₂N₂O₄
- canonical SMILES
- C1=C2C(=CC(=C1Cl)Cl)N(C=N2)C3C(C(C(O3)CO)O)O
- isomeric SMILES
- C1=C2C(=CC(=C1Cl)Cl)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
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5,6-Dichloro-1-β--ribofuranosylbenzimidazole (DRB) is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF), and positive transcription elongation factor b (P-TEFb). DRB is a nucleoside analog and also inhibits some protein kinases.
== References ==