Structure via PubChem · Public domain (PubChem)
۵،۶-دیکلرو-۱-بتا-دی-ریبوفورانوسیلبنزیمیدازول
Sign in to saveAlso known as 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole, 5,6-dichlororibofuranosylbenzimidazole, dichlororibofuranosylbenzimidazole, 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole
5,6-Dichloro-1-β--ribofuranosylbenzimidazole (DRB) is a chemical compound that inhibits transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF), and positive transcription elongation factor b (P-TEFb). DRB is a nucleoside analog and also inhibits some protein kinases.
Chemical data
- Formula
- C12H12Cl2N2O4
- Molecular weight
- 319.14 g/mol
- IUPAC name
- (2R,3R,4S,5R)-2-(5,6-dichlorobenzimidazol-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol
- SMILES
- C1=C2C(=CC(=C1Cl)Cl)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
- InChIKey
- XHSQDZXAVJRBMX-DDHJBXDOSA-N
- XLogP
- 1.1
- Polar surface area
- 87.7 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Mass
- 318.017
Show 5 more facts
- Commons category
- 5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole
- chemical formula
- C₁₂H₁₂Cl₂N₂O₄
- canonical SMILES
- C1=C2C(=CC(=C1Cl)Cl)N(C=N2)C3C(C(C(O3)CO)O)O
- isomeric SMILES
- C1=C2C(=CC(=C1Cl)Cl)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
- subject has role
- DNA polymerase inhibitors
Sources (2)
via Wikidata · CC0