epothilones
Sign in to saveAlso known as epothilone
{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" ! | Epothilones |- | align="center" colspan="2" bgcolor="#ffffff"| 250px|Epothilones A (R = H) and B (R = Me) Epothilones A (R = H) and B (R = CH3) |- | Chemical formulae | A: C26H39NO6S B: C27H41NO6S |- | Molecular masses | A: 493.66 g/mol B: 507.68 g/mol |- | CAS numbers | A: 152044-53-6 B: 152044-54-7 |- | PubChem | A: 448799 B: 448013 |- | align="center" colspan="2" bgcolor="#ffffff"| 250px|Epothilones C (R = H) and D (R = Me) Epothilones C (R = H) and D (R = CH3) |- | Chemi
Research
1,440 papers- Epothilones as Natural Compounds for Novel Anticancer Drugs Development.International journal of molecular sciences · 2023
- Epothilones: clinical update and future directions.Oncology (Williston Park, N.Y.) · 2008
- Epothilones: a novel class of non-taxane microtubule-stabilizing agents.Current pharmaceutical design · 2002
- Epothilones in the treatment of cancer.Expert opinion on investigational drugs · 2006
- Synthesis & antitumor activity of epothilones B and D and their analogs.Future medicinal chemistry · 2018
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- Epothilones
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Article
7 sectionsContents
- History
- Mechanism of action
- Medical use and research
- Total synthesis
- Biosynthesis
- See also
- References
{| class="toccolours" border="1" style="float: right; clear: right; margin: 0 0 1em 1em; border-collapse: collapse;" ! | Epothilones |- | align="center" colspan="2" bgcolor="#ffffff"| 250px|Epothilones A (R = H) and B (R = Me) Epothilones A (R = H) and B (R = CH3) |- | Chemical formulae | A: C26H39NO6S B: C27H41NO6S |- | Molecular masses | A: 493.66 g/mol B: 507.68 g/mol |- | CAS numbers | A: 152044-53-6 B: 152044-54-7 |- | PubChem | A: 448799 B: 448013 |- | align="center" colspan="2" bgcolor="#ffffff"| 250px|Epothilones C (R = H) and D (R = Me) Epothilones C (R = H) and D (R = CH3) |- | Chemical formulae | C: C26H39NO5S D: C27H41NO5S |- | Molecular masses | C: 477.66 g/mol D: 491.68 g/mol |- | CAS numbers | C: 186692-73-9 D: 189453-10-9 |- | PubChem | C: 9891226 D: 447865 |- | align="center" colspan="2" bgcolor="#ffffff"| 250px|Epothilones E (R = H) and F (R = Me) Epothilones E (R = H) and F (R = CH3) |- | Chemical formulae | E: C26H39NO7S F: C27H41NO7S |- | Molecular masses | E: 509.66 g/mol F: 523.68 g/mol |- | CAS numbers | E: 201049-37-8 F: 208518-52-9 |- | PubChem | E: 9806341 F: 9914741 |- | | Disclaimer and references |}
Epothilones are a class of potential cancer drugs. Like taxanes, they prevent cancer cells from dividing by interfering with tubulin, but in early trials, epothilones have better efficacy and milder adverse effects than taxanes.
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