EXOSC10
Sign in to saveAlso known as PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3
protein-coding gene in the species Homo sapiens
Gene data
EXOSC10- Name
- exosome component 10
- Type
- protein-coding
- Position
- 11,066,613–11,099,907 (−)
- Aliases
- PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4
- Ensembl
- ENSG00000171824
- RefSeq RNA
- NM_001001998.3, NM_002685.4, XM_005263475.3, XM_047422661.1, XM_047422663.1
- RefSeq protein
- NP_001001998.1, NP_002676.1, XP_005263532.2, XP_047278617.1, XP_047278619.1
Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via telomerase. Located in cytosol; nuclear lumen; and transcriptionally active chromatin. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
maturation of 5.8S rRNAexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)nuclear-transcribed mRNA catabolic processrRNA processingRNA processingRNA processingRNA catabolic process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
exosome component 10
- Symbol
- EXOSC10
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:11,066,613-11,099,907
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein EXOSC10 PDB 2cpr.png
Show 8 more facts
- HomoloGene ID
- 31105
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/5394
- cytogenetic location
- 1p36.22
- genomic end
- 11099869
- genomic start
- 11126675
- chromosome
- human chromosome 1
- Commons category
- Exosome component 10, EXOSC10
Sources (4)
via Wikidata · CC0