fibromyalgia

Also known as Fibromyalgia Syndrome, FM

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Key facts

Medical condition.name: Fibromyalgia
Medical condition.image: Widespread Pain Index Areas.svg
Medical condition.caption: Possible pain areas in the most used fibromyalgia diagnosis criteria (ACR 2016)
Medical condition.field: rheumatology, neurology
Medical condition.synonyms: Fibromyalgia syndrome
Medical condition.symptoms: Widespread pain, fatigue, sleep problems
Medical condition.onset: Early–middle age
Medical condition.duration: Long term
Medical condition.causes: Uncertain
Medical condition.diagnosis: Based on symptoms after ruling out other potential causes
Medical condition.differential: Anemia, autoimmune disorders (such as ankylosing spondylitis, polymyalgia rheumatica, rheumatoid arthritis, scleroderma, or multiple sclerosis), Lyme disease, osteoarthritis, thyroid disease
Medical condition.treatment: Sufficient sleep and exercise, medication
Medical condition.medication: Cyclobenzaprine, duloxetine, milnacipran, pregabalin
Medical condition.prognosis: Normal life expectancy
Medical condition.frequency: 2%

via Wikipedia infobox

Research

16,722 papers

Fibromyalgia: a clinical review.ReviewJAMA · 2014Clauw DJDOI: 10.1001/jama.2014.3266
Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment.Nature reviews. Rheumatology · 2020Sarzi-Puttini P, Giorgi V, Marotto D et al.DOI: 10.1038/s41584-020-00506-w
Fibromyalgia.ReviewAnnals of internal medicine · 2020Bair MJ, Krebs EEDOI: 10.7326/AITC202003030
Fibromyalgia and Inflammation: Unrevealing the Connection.ReviewCells · 2025García-Domínguez MDOI: 10.3390/cells14040271
Fibromyalgia Pathogenesis and Treatment Options Update.ReviewCurrent pain and headache reports · 2016Chinn S, Caldwell W, Gritsenko KDOI: 10.1007/s11916-016-0556-x
Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers.ReviewMolecular pain · 2019D'Agnelli S, Arendt-Nielsen L, Gerra MC et al.DOI: 10.1177/1744806918819944
Fibromyalgia.ReviewDisease-a-month : DM · 2015Jay GW, Barkin RLDOI: 10.1016/j.disamonth.2015.01.002
Fibromyalgia.ReviewBMJ (Clinical research ed.) · 2014Rahman A, Underwood M, Carnes DDOI: 10.1136/bmj.g1224

via PubMed

Wikidata facts

Image: Tender points fibromyalgia.svg

Show 5 more facts

NCI Thesaurus ID: C50566
Commons category: Fibromyalgia
ICPC 2 ID: L18
exact match: identifiers.org/doid/DOID:631
ICD-9-CM: 729.1

Sources (8)

via Wikidata · CC0

~59 min read

Article

55 sections

Contents

Terminology
Classification
ICD-11
Other classifications
Subgroups or clusters within FM
Signs and symptoms
Chronic pain
Fatigue
Sleep problems
Cognitive problems ("fibro fog")
Other signs and symptoms
Comorbidity
Causal and risk factors
Genetics
Stress and adverse life experiences
Other risk markers
Factors found not to correlate with fibromyalgia
Pathophysiology
Nervous system
Central nervous system
Peripheral and autonomic nervous systems
Neurochemical and neuroendocrine
Metabolic and proteomic evidence
Immune system
Digestive system
Diagnosis
Diagnostic criteria
Scales for fibromyalgia severity
Differential diagnosis
Epidemiology
Prognosis
Management
Mental tools
Exercise
Aerobic
Resistance
Other exercise types
Medications
Antidepressants
Anti-seizure medication
Opioids
Muscle relaxants
Other medications
Nutrition and dietary supplements
Physical therapy
Electrical neuromodulation
Other interventions
Society and culture
History
Origins
Controversies on the nature and reality of fibromyalgia
History of fibromyalgia diagnosis
Notes
References
External links

Fibromyalgia (FM) is a long-term adverse health condition characterised by widespread chronic pain. Current diagnosis also requires an above-threshold severity score from among six other symptoms: fatigue, trouble thinking or remembering, waking up tired (unrefreshed), pain or cramps in the lower abdomen, depression, or headache. Other symptoms may also be experienced. The causes of fibromyalgia are unknown, with several pathophysiologies proposed.

Fibromyalgia is estimated to affect 2 to 4% of the population. Women are affected at a higher rate than men. Rates appear similar across areas of the world and among varied cultures. Fibromyalgia was first recognised in the 1950s, and defined in 1990, with updated criteria in 2011, 2016, and 2019.