FLOT2
Sign in to saveAlso known as ECS-1, ECS1, ESA, ESA1, M17S1, flotillin 2
Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene. Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may influence tumour progression.
Gene data
FLOT2- Name
- flotillin 2
- Type
- protein-coding
- Aliases
- ECS-1, ECS1, ESA, ESA1, M17S1
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
flotillin 2
- Symbol
- FLOT2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:28,879,335-28,897,741
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein FLOT2 PDB 1win.png
Show 5 more facts
- HomoloGene ID
- 3293
- exact match
- identifiers.org/ncbigene/2319
- genomic end
- 28897733
- genomic start
- 27206353
- cytogenetic location
- 17q11.2
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene. Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to PAR-1, a known upstream mediator of major signal transduction pathways implicated in cell growth and metastasis, and may influence tumour progression.
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. This gene encodes a caveolae-associated, integral membrane protein, which is thought to function in neuronal signaling.