fluvoxamine

Also known as Luvox®, U-23000, Fluvoxaminum, Fluvoxamina

Fluvoxamine, sold under the brand name Luvox among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is primarily used to treat major depressive disorder and, perhaps more-especially, obsessive–compulsive disorder (OCD), but is also used to treat anxiety disorders such as panic disorder, social anxiety disorder, and post-traumatic stress disorder.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 443824781
Drug.image: Fluvoxamine.svg
Drug.image_class: skin-invert-image
Drug.image2: FLUVOXAMINE_3d-ball-and-stick.png
Drug.image_class2: bg-transparent
Drug.width2: 276
Drug.pronounce: UK: US:
Drug.tradename: Luvox, others
Drug.MedlinePlus: a695004
Drug.DailyMedID: Fluvoxamine
Drug.pregnancy_AU: C
Drug.routes_of_administration: By mouth
Drug.class: Selective serotonin reuptake inhibitor (SSRI)
Drug.ATC_prefix: N06
Drug.ATC_suffix: AB08
Drug.legal_AU: S4

via Wikipedia infobox

Chemical data

Formula: C15H21F3N2O2
Molecular weight: 318.33 g/mol
IUPAC name: 2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine
SMILES: COCCCC/C(=N\OCCN)/C1=CC=C(C=C1)C(F)(F)F
InChIKey: CJOFXWAVKWHTFT-XSFVSMFZSA-N
XLogP: 2.6
Polar surface area: 56.8 Å²
H-bond donors: 1
H-bond acceptors: 7
Formal charge: 0

via PubChem

Research

3,573 papers

Fluvoxamine for symptomatic outpatients with COVID-19.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2022
[Fluvoxamine in the treatment of anxiety-depressive spectrum disorders].Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2024
Adjunctive Fluvoxamine for Schizophrenia: A Meta-analysis of Randomized Double-Blind, Placebo-Controlled Trials.Journal of clinical psychopharmacology · 2020
Fluvoxamine for the Early Treatment of SARS-CoV-2 Infection: A Review of Current Evidence.Drugs · 2021
Lack of Benefit of Fluvoxamine for COVID-19.JAMA · 2023

via PubMed

Wikidata facts

Mass: 318.156

Show 7 more facts

chemical formula: C₁₅H₂₁F₃N₂O₂
isomeric SMILES: COCCCC/C(=N\OCCN)/C1=CC=C(C=C1)C(F)(F)F
canonical SMILES: COCCCCC(=NOCCN)C1=CC=C(C=C1)C(F)(F)F
World Health Organisation international non-proprietary name: fluvoxamine
Commons category: Fluvoxamine
defined daily dose: 0.1
stylized name: fluvoxaMINE

Sources (8)

via Wikidata · CC0

~17 min read

Article

14 sections

Contents

Medical uses
Adverse effects
Common
Uncommon
Rare
Unknown frequency
Interactions
Pharmacology
Pharmacodynamics
Pharmacokinetics
History
Research directions
Environment
References

{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 443824781 | image = Fluvoxamine.svg | image_class = skin-invert-image | width = | alt = | caption = | image2 = FLUVOXAMINE_3d-ball-and-stick.png | image_class2 = bg-transparent | width2 = 276 | alt2 = | pronounce = UK: US: | tradename = Luvox, others | Drugs.com = | MedlinePlus = a695004 | DailyMedID = Fluvoxamine | pregnancy_AU = C | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = Selective serotonin reuptake inhibitor (SSRI) | ATC_prefix = N06 | ATC_suffix = AB08 | ATC_supplemental = | legal_AU = S4 | legal_AU_comment = | legal_BR = C1 | legal_BR_comment = | legal_CA = Rx-only | legal_CA_comment = | legal_DE = | legal_DE_comment = | legal_NZ = | legal_NZ_comment = | legal_UK = POM | legal_UK_comment = | legal_US = Rx-only | legal_US_comment = | legal_UN = | legal_UN_comment = | legal_status =

| bioavailability = 53% (90% confidence interval: 44–62%) | protein_bound = 77–80% | metabolism = Liver (primarily O-demethylation)Major: CYP2D6 or CYP1A2Minor: CYP3A4, CYP2C19, and/or CYP1A2 | metabolites = | onset = | elimination_half-life = 12–13 hours (single dose), 22 hours (repeated dosing) | duration_of_action = | excretion = Kidney (98%; 94% as metabolites, 4% as unchanged drug)