Structure via PubChem · Public domain (PubChem)
fomepizole
Sign in to saveAlso known as 4-MP, 4-Methylpyrazol, Antizol, 4-methylpyrazole, Fomepizol, Fomepizolum
Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol and ethylene glycol poisoning. It may be used alone or together with hemodialysis. It is given by injection into a vein.
In the Vinony graph
Within Vinony's link graph, fomepizole is referenced by 103 other articles, and connects out to World Health Organization, liver and human pregnancy.
Vinony files it under Alcohol dehydrogenase inhibitors, Antidotes and ECHA InfoCard ID from Wikidata.
Its subject is documented across 32 Wikipedia language editions.
Key facts
- Drug.image
- Fomepizole.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 125
- Drug.alt
- Skeletal formula of fomepizole
- Drug.image2
- Fomepizole 3D ball.png
- Drug.width2
- 125
- Drug.alt2
- Ball-and-stick model of the fomepizole molecule
- Drug.caption
- Chemical structure of fomepizole
- Drug.tradename
- Antizol, others
- Drug.DailyMedID
- Fomepizole
- Drug.routes_of_administration
- Intravenous
- Drug.ATC_prefix
- V03
- Drug.ATC_suffix
- AB34
- Drug.legal_AU
- S4
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 7554-65-6
- Drug.PubChem
- 3406
- Drug.DrugBank
- DB01213
via Wikipedia infobox
Chemical data
- Formula
- C4H6N2
- Molecular weight
- 82.1 g/mol
- IUPAC name
- 4-methyl-1H-pyrazole
- SMILES
- CC1=CNN=C1
- InChIKey
- RIKMMFOAQPJVMX-UHFFFAOYSA-N
- XLogP
- 1.4
- Polar surface area
- 28.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1997
- Admin. routes
- parenteral
- Indications
- age-related macular degeneration
via ChEMBL · EBI
Research
761 papers- Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review.Toxicology letters · 2022
- Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings.Clinical toxicology (Philadelphia, Pa.) · 2010
- [Fomepizole, ethanol or dialysis in the case of life-threatening ethylenglycol intoxication?].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021
- Fomepizole should be used more liberally in paracetamol overdose.British journal of clinical pharmacology · 2023
- Fomepizole should not be used more liberally in paracetamol overdose.British journal of clinical pharmacology · 2023
via PubMed
Wikidata facts
- Subclass of
- heterocyclic compound
- Has part
- carbon
- Mass
- 82.053
- Has use
- medication
Show 7 more facts
- melting point
- 13
- chemical formula
- C₄H₆N₂
- canonical SMILES
- CC1=CNN=C1
- World Health Organisation international non-proprietary name
- fomepizole
- subject has role
- essential medicine
- Commons category
- Fomepizole
- legal status (medicine)
- boxed warning
via Wikidata · CC0
~4 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Adverse effects
- Interactions
- Interaction with ethanol
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Absorption and distribution
- Metabolism and elimination
- References
Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol and ethylene glycol poisoning. It may be used alone or together with hemodialysis. It is given by injection into a vein.
Common side effects include headache, nausea, sleepiness, and unsteadiness. It is unclear if use during pregnancy causes risk to a fetus. Fomepizole works by blocking the enzyme that converts methanol and ethylene glycol to their toxic breakdown products.
Excerpted from Wikipedia’s “fomepizole” article, available under the CC BY-SA 4.0 licence.