Structure via PubChem · Public domain (PubChem)
gabexate
Sign in to saveGabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis.
In the Vinony graph
Within Vinony's link graph, gabexate is referenced by 3 other articles, and connects out to blood, medication and digital object identifier.
It is catalogued under topics including Benzoate esters, Chemical pages without DrugBank identifier and Drugboxes which contain changes to verified fields.
Its subject is documented across 6 Wikipedia language editions.
Chemical data
- Formula
- C16H23N3O4
- Molecular weight
- 321.37 g/mol
- IUPAC name
- ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate
- SMILES
- CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N
- InChIKey
- YKGYIDJEEQRWQH-UHFFFAOYSA-N
- XLogP
- 1.4
- Polar surface area
- 117 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- liver disease
via ChEMBL · EBI
Research
928 papers- Efficacy of gabexate mesilate in preventing post endoscopic retrograde cholangiopancreatography pancreatitis: A meta-analysis of randomized clinical trials.Journal of the Formosan Medical Association = Taiwan yi zhi · 2021
- Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials.BMC gastroenterology · 2007
- Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial.Gastrointestinal endoscopy · 2002
- Use of gabexate mesylate in Italian hospitals: a multicentre observational study.Journal of clinical pharmacy and therapeutics · 2003
- Somatostatin and gabexate for post-endoscopic retrograde cholangiopancreatography pancreatitis prevention: meta-analysis of randomized placebo-controlled trials.Journal of gastroenterology and hepatology · 2007
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 321.169
- Has use
- medication
Show 2 more facts
- chemical formula
- C₁₆H₂₃N₃O₄
- canonical SMILES
- CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Gabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular coagulation, and as a regional anticoagulant for haemodialysis.
== References ==
Excerpted from Wikipedia’s “gabexate” article, available under the CC BY-SA 4.0 licence.