GAS2

Also known as growth arrest specific 2, GAS-2

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.

Gene data

GAS2

Name: growth arrest specific 2
Type: protein-coding
Position: 22,625,509–22,813,803 (+)
Aliases: DFNB125, GAS-2
Ensembl: ENSG00000148935
RefSeq RNA: NM_001143830.3, NM_001351224.3, NM_001391933.1, NM_001391934.1, NM_001391935.1
RefSeq protein: NP_001137302.1, NP_001338153.1, NP_001378862.1, NP_001378863.1, NP_001378864.1

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017].

Gene Ontology

Biological process

apoptotic process actin crosslink formation

Article

2 sections

Contents

References
Further reading

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.