GAS2
Sign in to saveAlso known as growth arrest specific 2, GAS-2
Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.
Gene data
GAS2- Name
- growth arrest specific 2
- Type
- protein-coding
- Position
- 22,625,509–22,813,803 (+)
- Aliases
- DFNB125, GAS-2
- Ensembl
- ENSG00000148935
- RefSeq RNA
- NM_001143830.3, NM_001351224.3, NM_001391933.1, NM_001391934.1, NM_001391935.1
- RefSeq protein
- NP_001137302.1, NP_001338153.1, NP_001378862.1, NP_001378863.1, NP_001378864.1
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
growth arrest specific 2
- Symbol
- GAS2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:22,625,509-22,813,803
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein GAS2 PDB 1v5r.png
Show 5 more facts
- HomoloGene ID
- 31301
- exact match
- identifiers.org/ncbigene/2620
- genomic end
- 22813001
- genomic start
- 22625509
- cytogenetic location
- 11p14.3
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.
The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.