GAS2

Also known as growth arrest specific 2, GAS-2

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.

Gene data

GAS2

Name: growth arrest specific 2
Type: protein-coding
Position: 22,625,509–22,813,803 (+)
Aliases: DFNB125, GAS-2
Ensembl: ENSG00000148935
RefSeq RNA: NM_001143830.3, NM_001351224.3, NM_001391933.1, NM_001391934.1, NM_001391935.1
RefSeq protein: NP_001137302.1, NP_001338153.1, NP_001378862.1, NP_001378863.1, NP_001378864.1

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017].

Gene Ontology

Biological process

apoptotic process actin crosslink formation

Molecular function

protein binding microtubule binding actin filament binding

Cellular component

stress fiber cytosol actin filament membrane membrane

Pathways

Apoptosis Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Programmed Cell Death Apoptotic execution phase

via MyGene.info

Gene · Ensembl

growth arrest specific 2

Symbol: GAS2
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:22,625,509-22,813,803
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein GAS2 PDB 1v5r.png

Show 8 more facts

HomoloGene ID: 31301
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/2620
genomic end: 22813001
genomic start: 22625509
chromosome: human chromosome 11
cytogenetic location: 11p14.3
expressed in: spinal ganglia

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Encyclopedic overview

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Contents

References
Further reading

Growth arrest-specific protein 2 is a protein that in humans is encoded by the GAS2 gene.

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Excerpted from Wikipedia’s “GAS2” article, available under the CC BY-SA 4.0 licence.

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