GIPC3
Sign in to saveAlso known as C19orf64, DFNB15, DFNB72, DFNB95, GIPC PDZ domain containing family member 3
PDZ domain-containing protein GIPC3 is a protein that in humans is encoded by the GIPC3 gene. GIPC3 is a member of the GIPC (GAIP-interacting protein C terminus) gene family that also includes GIPC1 and GIPC2. The encoded protein, GIPC3, features a centrally located PDZ domain, which is flanked on each side by a single GIPC-homology domain.
Gene data
GIPC3- Name
- GIPC PDZ domain containing family member 3
- Type
- protein-coding
- Position
- 3,585,474–3,593,541 (+)
- Aliases
- C19orf64, DFNB15, DFNB72, DFNB95
- Ensembl
- ENSG00000179855
- RefSeq RNA
- NM_001411144.1, NM_133261.3, XM_054319804.1
- RefSeq protein
- NP_001398073.1, NP_573568.1, XP_054175779.1
The protein encoded by this gene belongs to the GIPC family. Studies in mice suggest that this gene is required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion in the ear. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2011].
Gene Ontology
Molecular function
via MyGene.info
Gene · Ensembl
GIPC PDZ domain containing family member 3
- Symbol
- GIPC3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:3,585,474-3,593,541
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~3 min read
Encyclopedic overview
8 sectionsContents
- Function
- Gene
- Genetics
- Phenotypes
- Interactions
- See also
- References
- Further reading
PDZ domain-containing protein GIPC3 is a protein that in humans is encoded by the GIPC3 gene. GIPC3 is a member of the GIPC (GAIP-interacting protein C terminus) gene family that also includes GIPC1 and GIPC2. The encoded protein, GIPC3, features a centrally located PDZ domain, which is flanked on each side by a single GIPC-homology domain.
==Function== GIPC3 is thought to be important for acoustic signal acquisition and propagation in hair cells of the mammalian cochlea.
Excerpted from Wikipedia’s “GIPC3” article, available under the CC BY-SA 4.0 licence.