Structure via PubChem · Public domain (PubChem)
givinostat
Sign in to saveAlso known as gavinostat, ITF-2357, ITF2357, {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate
Givinostat, sold under the brand name Duvyzat is a medication used for the treatment of Duchenne muscular dystrophy. It is a histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. It is a histone deacetylase (HDAC) inhibitor that works by targeting pathogenic processes to reduce inflammation and loss of muscle.
In the Vinony graph
Within Vinony's link graph, givinostat is referenced by 65 other articles, and connects out to valproic acid, sodium phenylbutyrate and medication.
It is catalogued under topics including Diethylamino compounds, Drugboxes which contain changes to verified fields and Drugboxes which contain changes to watched fields.
Its subject is documented across 7 Wikipedia language editions.
Chemical data
- Formula
- C24H27N3O4
- Molecular weight
- 421.5 g/mol
- IUPAC name
- [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
- SMILES
- CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO
- InChIKey
- YALNUENQHAQXEA-UHFFFAOYSA-N
- XLogP
- 3.6
- Polar surface area
- 90.9 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2024
- Admin. routes
- oral
- Indications
- chronic lymphocytic leukemia, Hodgkins lymphoma, Crohn's disease, multiple myeloma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- angiogenesis inhibitor
- Mass
- 421.200156
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₄H₂₇N₃O₄
- canonical SMILES
- CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO
- inhibitor of
- growth
- route of administration
- oral administration
- World Health Organisation international non-proprietary name
- givinostatum
Sources (2)
via Wikidata · CC0
~8 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Adverse effects
- Mechanism of action
- History
- Society and culture
- Legal status
- Names
- Research
- References
- Further reading
{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451563965 | image = Givinostat structure.svg | image_class = skin-invert-image | alt = | width = | caption =
| pronounce = | tradename = Duvyzat | Drugs.com = | MedlinePlus = a624025 | DailyMedID = Givinostat | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth | class = Histone deacetylase inhibitor | ATC_prefix = M09 | ATC_suffix = AX14 | ATC_supplemental =
Excerpted from Wikipedia’s “givinostat” article, available under the CC BY-SA 4.0 licence.