panobinostat

Also known as LBH589, Farydak®, LBH-589, LBH 589, (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide

Panobinostat, sold under the brand name Farydak, is a medication used for the treatment of multiple myeloma. It is a hydroxamic acid and acts as a non-selective histone deacetylase inhibitor (pan-HDAC inhibitor).

Chemical data

Formula: C21H23N3O2
Molecular weight: 349.4 g/mol
IUPAC name: (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
SMILES: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
InChIKey: FPOHNWQLNRZRFC-ZHACJKMWSA-N
XLogP: 3
Polar surface area: 77.2 Å²
H-bond donors: 4
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2015
Admin. routes: oral
Indications: neoplasm, multiple myeloma, Cutaneous T-cell lymphoma, diffuse large B-cell lymphoma

via ChEMBL · EBI

Research

1,263 papers

Panobinostat: first global approval.Drugs · 2015
Panobinostat From Bench to Bedside: Rethinking the Treatment Paradigm for Multiple Myeloma.Clinical lymphoma, myeloma & leukemia · 2021
Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a.Cell · 2024
Panobinostat for the management of multiple myeloma.Future oncology (London, England) · 2017
Panobinostat for the Treatment of Multiple Myeloma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015

via PubMed

Wikidata facts

Mass: 349.179
Has use: medication

Show 7 more facts

chemical formula: C₂₁H₂₃N₃O₂
canonical SMILES: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
isomeric SMILES: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
World Health Organisation international non-proprietary name: panobinostat
subject has role: antineoplastic
significant drug interaction: ketoconazole
Commons category: Panobinostat

Sources (5)

via Wikidata · CC0

~6 min read

Encyclopedic overview

9 sections

Contents

Medical uses
Contraindications
Side effects
Pharmacology
Mechanism of action
Pharmacokinetics
Clinical trials
Preclinical studies
References

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Excerpted from Wikipedia’s “panobinostat” article, available under the CC BY-SA 4.0 licence.

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