panobinostat
Sign in to saveAlso known as LBH589, Farydak®, LBH-589, LBH 589, (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide
Panobinostat, sold under the brand name Farydak, is a medication used for the treatment of multiple myeloma. It is a hydroxamic acid and acts as a non-selective histone deacetylase inhibitor (pan-HDAC inhibitor).
In the Vinony graph
Vinony's link graph records 316 inbound references to panobinostat, and connects out to valproic acid, sodium phenylbutyrate and tiazofurin.
It is catalogued under topics including Cancer treatments, CYP2D6 inhibitors and Drugboxes which contain changes to verified fields.
Vinony links it to 14 Wikipedia language editions.
Research
1,263 papers- Panobinostat: first global approval.Drugs · 2015
- Panobinostat From Bench to Bedside: Rethinking the Treatment Paradigm for Multiple Myeloma.Clinical lymphoma, myeloma & leukemia · 2021
- Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a.Cell · 2024
- Panobinostat for the management of multiple myeloma.Future oncology (London, England) · 2017
- Panobinostat for the Treatment of Multiple Myeloma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015
via PubMed
Wikidata facts
- Mass
- 349.179
Show 5 more facts
- chemical formula
- C₂₁H₂₃N₃O₂
- canonical SMILES
- CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)C=CC(=O)NO
- isomeric SMILES
- CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
- World Health Organisation international non-proprietary name
- panobinostat
- Commons category
- Panobinostat
Sources (5)
via Wikidata · CC0
~6 min read
Encyclopedic overview
9 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Clinical trials
- Preclinical studies
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 455315413 | image = Panobinostat.svg | image_class = skin-invert-image | width = 275 | alt =
| pronounce = | tradename = Farydak | Drugs.com = | DailyMedID = Panobinostat | pregnancy_AU = | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = L01 | ATC_suffix = XH03 | ATC_supplemental =
Excerpted from Wikipedia’s “panobinostat” article, available under the CC BY-SA 4.0 licence.
Available in 14 languages
- Español
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