GLMN

Also known as FAP, FAP48, FAP68, FKBPAP, GLML, GVM, VMGLOM, glomulin, FKBP associated protein

Glomulin is a protein that in humans is encoded by the GLMN gene.

Gene data

GLMN

Name: glomulin, FKBP associated protein
Type: protein-coding
Position: 92,245,786–92,299,009 (−)
Aliases: FAP, FAP48, FAP68, FKBPAP, GLML, GVM, VMGLOM
Ensembl: ENSG00000174842
RefSeq RNA: NM_001319683.2, NM_007070.2, NM_053274.3, NR_135089.2, XM_005270401.4
RefSeq protein: NP_001306612.1, NP_444504.1, XP_005270458.1, XP_006710372.1, XP_011538848.1

This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016].

Gene Ontology

Biological process

vasculogenesis vasculogenesis positive regulation of cytokine production cell surface receptor signaling pathway negative regulation of cell population proliferation regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of interleukin-2 production

Molecular function

signaling receptor binding hepatocyte growth factor receptor binding hepatocyte growth factor receptor binding protein binding ubiquitin protein ligase binding ubiquitin-protein transferase inhibitor activity ubiquitin-protein transferase inhibitor activity

Cellular component

cytoplasm cullin-RING ubiquitin ligase complex cullin-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex Cul3-RING ubiquitin ligase complex Cul4A-RING E3 ubiquitin ligase complex

Pathways

Shigellosis - Homo sapiens (human)Adaptive Immune System Immune System Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation

via MyGene.info

Gene · Ensembl

glomulin, FKBP associated protein

Symbol: GLMN
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:92,245,786-92,299,009
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 14239
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/11146
genomic end: 92764544
genomic start: 92711959
chromosome: human chromosome 1
cytogenetic location: 1p22.1

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Interactions
References
Further reading

Glomulin is a protein that in humans is encoded by the GLMN gene.

This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

Excerpted from Wikipedia’s “GLMN” article, available under the CC BY-SA 4.0 licence.

Available in 8 languages

via Wikidata sitelinks · CC0

What links here6 pages

FKBP4

Gene

MET proto-oncogene, receptor tyrosine kinase