Golodirsen

Golodirsen, sold under the brand name Vyondys 53, is a medication used for the treatment of Duchenne muscular dystrophy. It is an antisense oligonucleotide medication of phosphorodiamidate morpholino oligomer (PMO) chemistry.

In the Vinony graph

Vinony's link graph records 30 inbound references to Golodirsen, and connects out to medical treatment, adult and intravenous infusion and defusion.

Vinony files it under Antisense RNA, Chemical articles having Jmol set and Chemical articles having Jmol set/None.

Vinony links it to 6 Wikipedia language editions.

Wikidata facts

Subclass of: chemical compound
Mass: 8642.962530582005

Show 3 more facts

isomeric SMILES: Cc1cn([C@H]2CN(P(=O)(OC[C@@H]3CN(P(=O)(OC[C@@H]4CN(P(=O)(OC[C@@H]5CN(P(=O)(OC[C@@H]6CN(P(=O)(OC[C@@H]7CN(P(=O)(OC[C@@H]8CN(P(=O)(OC[C@@H]9CN(P(=O)(OC[C@@H]%10CN(P(=O)(OC[C@@H]%11CN(P(=O)(OC[C@@H]%12CN(P(=O)(OC[C@@H]%13CN(P(=O)(OC[C@@H]%14CN(P(=O)(OC[C@@H]%15CN(P(=O)(OC[C@@H]%16CN(P(=O)(OC[C@@H]%17CN(P(=O)(OC[C@@H]%18CN(P(=O)(OC[C@@H]%19CN(P(=O)(OC[C@@H]%20CNC[C@H](n%21ccc(N)nc%21=O)O%20)N(C)C)C[C@H](n%20cc(C)c(=O)[nH]c%20=O)O%19)N(C)C)C[C@H](n%19cc(C)c(=O)[nH]c%19=O)O%18)N(C)C)C[C@H](n%18cnc%19c(=O)[nH]c(N)nc%19%18)O%17)N(C)C)C[C@H](n%17cc(C)c(=O)[nH]c%17=O)O%16)N(C)C)C[C@H](n%16cnc%17c(=O)[nH]c(N)nc%17%16)O%15)N(C)C)C[C@H](n%15cnc%16c(=O)[nH]c(N)nc%16%15)O%14)N(C)C)C[C@H](n%14cnc%15c(N)ncnc%15%14)O%13)N(C)C)C[C@H](n%13cnc%14c(N)ncnc%14%13)O%12)N(C)C)C[C@H](n%12cnc%13c(=O)[nH]c(N)nc%13%12)O%11)N(C)C)C[C@H](n%11cc(C)c(=O)[nH]c%11=O)O%10)N(C)C)C[C@H](n%10ccc(N)nc%10=O)O9)N(C)C)C[C@H](n9cc(C)c(=O)[nH]c9=O)O8)N(C)C)C[C@H](n8cc(C)c(=O)[nH]c8=O)O7)N(C)C)C[C@H](n7cnc8c(=O)[nH]c(N)nc87)O6)N(C)C)C[C@H](n6cnc7c(=O)[nH]c(N)nc76)O5)N(C)C)C[C@H](n5ccc(N)nc5=O)O4)N(C)C)C[C@H](n4ccc(N)nc4=O)O3)N(C)C)C[C@@H](COP(=O)(N(C)C)N3C[C@@H](COP(=O)(N(C)C)N4C[C@@H](COP(=O)(N(C)C)N5C[C@@H](COP(=O)(N(C)C)N6C[C@@H](COP(=O)(N(C)C)N7C[C@@H](COP(=O)(N(C)C)N8C[C@@H](COP(=O)(N(C)C)N9CCN(C(=O)OCCOCCOCCO)CC9)O[C@@H](n9cnc%10c(=O)[nH]c(N)nc%109)C8)O[C@@H](n8cc(C)c(=O)[nH]c8=O)C7)O[C@@H](n7cc(C)c(=O)[nH]c7=O)C6)O[C@@H](n6cnc7c(=O)[nH]c(N)nc76)C5)O[C@@H](n5ccc(N)nc5=O)C4)O[C@@H](n4ccc(N)nc4=O)C3)O2)c(=O)[nH]c1=O
chemical formula: C₃₀₅H₄₈₁N₁₃₈O₁₁₂P₂₅
canonical SMILES: Cc1cn(C2CN(P(=O)(OCC3CNCC(n4ccc(N)nc4=O)O3)N(C)C)CC(COP(=O)(N(C)C)N3CC(COP(=O)(N(C)C)N4CC(COP(=O)(N(C)C)N5CC(COP(=O)(N(C)C)N6CC(COP(=O)(N(C)C)N7CC(COP(=O)(N(C)C)N8CC(COP(=O)(N(C)C)N9CC(COP(=O)(N(C)C)N%10CC(COP(=O)(N(C)C)N%11CC(COP(=O)(N(C)C)N%12CC(COP(=O)(N(C)C)N%13CC(COP(=O)(N(C)C)N%14CC(COP(=O)(N(C)C)N%15CC(COP(=O)(N(C)C)N%16CC(COP(=O)(N(C)C)N%17CC(COP(=O)(N(C)C)N%18CC(COP(=O)(N(C)C)N%19CC(COP(=O)(N(C)C)N%20CC(COP(=O)(N(C)C)N%21CC(COP(=O)(N(C)C)N%22CC(COP(=O)(N(C)C)N%23CC(COP(=O)(N(C)C)N%24CC(COP(=O)(N(C)C)N%25CC(COP(=O)(N(C)C)N%26CCN(C(=O)OCCOCCOCCO)CC%26)OC(n%26cnc%27c(=O)[nH]c(N)nc%27%26)C%25)OC(n%25cc(C)c(=O)[nH]c%25=O)C%24)OC(n%24cc(C)c(=O)[nH]c%24=O)C%23)OC(n%23cnc%24c(=O)[nH]c(N)nc%24%23)C%22)OC(n%22ccc(N)nc%22=O)C%21)OC(n%21ccc(N)nc%21=O)C%20)OC(n%20cc(C)c(=O)[nH]c%20=O)C%19)OC(n%19ccc(N)nc%19=O)C%18)OC(n%18ccc(N)nc%18=O)C%17)OC(n%17cnc%18c(=O)[nH]c(N)nc%18%17)C%16)OC(n%16cnc%17c(=O)[nH]c(N)nc%17%16)C%15)OC(n%15cc(C)c(=O)[nH]c%15=O)C%14)OC(n%14cc(C)c(=O)[nH]c%14=O)C%13)OC(n%13ccc(N)nc%13=O)C%12)OC(n%12cc(C)c(=O)[nH]c%12=O)C%11)OC(n%11cnc%12c(=O)[nH]c(N)nc%12%11)C%10)OC(n%10cnc%11c(N)ncnc%11%10)C9)OC(n9cnc%10c(N)ncnc%109)C8)OC(n8cnc9c(=O)[nH]c(N)nc98)C7)OC(n7cnc8c(=O)[nH]c(N)nc87)C6)OC(n6cc(C)c(=O)[nH]c6=O)C5)OC(n5cnc6c(=O)[nH]c(N)nc65)C4)OC(n4cc(C)c(=O)[nH]c4=O)C3)O2)c(=O)[nH]c1=O

Sources (1)