GPC3

Also known as DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1

protein-coding gene in the species Homo sapiens

Gene data

GPC3

Name: glypican 3
Type: protein-coding
Chromosome: X
Aliases: DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].

via MyGene.info