granuloma
A granuloma is an aggregation of macrophages (along with other cells) that forms in response to chronic inflammation. This occurs when the immune system attempts to isolate foreign substances that it is otherwise unable to eliminate. Such substances include infectious organisms including bacteria and fungi, as well as other materials such as foreign objects, keratin, and suture fragments.
Key facts
- Medical condition.caption
- Picture of a granuloma (without necrosis) as seen through a microscope on a glass slide: The tissue on the slide is stained with two standard dyes (hematoxylin: blue, eosin: pink) to make it visible. The granuloma in this picture was found in a lymph node of a patient with a Mycobacterium avium infection.
- Medical condition.field
- Pathology
- Medical condition.image
- Granuloma mac.jpg
via Wikipedia infobox
Research
67,016 papers- Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation.Immunity · 2023
- Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formation.mBio · 2025
- The Formation and Function of Granulomas.Annual review of immunology · 2018
- Cutaneous Granulomatosis: a Comprehensive Review.Clinical reviews in allergy & immunology · 2018
~12 min read
Article
25 sectionsContents
- Definition
- Caseating vs non-caseating
- Diseases with granulomas
- Tuberculosis
- Leprosy
- Aquarium granuloma
- Schistosomiasis
- Histoplasmosis
- Cryptococcosis
- Cat-scratch disease
- Rheumatic fever
- Sarcoidosis
- Crohn's disease
- ''Listeria monocytogenes''
- ''Leishmania'' spp.
- ''Pneumocystis'' pneumonia
- Aspiration pneumonia
- Rheumatoid arthritis
- Granuloma annulare
- Foreign-body granuloma
- Childhood granulomatous periorificial dermatitis
- Granulomas associated with vasculitis
- Etymology
- See also
- References
A granuloma is an aggregation of macrophages (along with other cells) that forms in response to chronic inflammation. This occurs when the immune system attempts to isolate foreign substances that it is otherwise unable to eliminate. Such substances include infectious organisms including bacteria and fungi, as well as other materials such as foreign objects, keratin, and suture fragments.
==Definition== In pathology, a granuloma is an organized collection of macrophages.