guvacine
Sign in to saveAlso known as 1,2,5,6-tetrahydronicotinic acid, 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid
Guvacine is a tetrahydropyridine alkaloid found in areca nuts. It is the N-demethylated derivative of arecaidine and the product of ester hydrolysis of guvacoline, both of which are also found in areca nuts as well. The compound is a potent and selective GABA reuptake inhibitor via GABA transporter 1 (GAT-1) inhibition. It shows poor blood–brain barrier penetration. Lime hydrolyzes guvacoline to guvacine.
Wikidata facts
- Subclass of
- alkaloid
- Mass
- 127.063329
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- chemical formula
- C₆H₉NO₂
- canonical SMILES
- C1CNCC(=C1)C(=O)O
- found in taxon
- Areca catechu
- Commons category
- Guvacine
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Encyclopedic overview
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- See also
- References
Guvacine is a tetrahydropyridine alkaloid found in areca nuts. It is the N-demethylated derivative of arecaidine and the product of ester hydrolysis of guvacoline, both of which are also found in areca nuts as well. The compound is a potent and selective GABA reuptake inhibitor via GABA transporter 1 (GAT-1) inhibition. It shows poor blood–brain barrier penetration. Lime hydrolyzes guvacoline to guvacine.
== See also == Nipecotic acid THPO Isoguvacine Tiagabine
Excerpted from Wikipedia’s “guvacine” article, available under the CC BY-SA 4.0 licence.