File:Haloperidol.svg · Wikimedia Commons · See Wikimedia Commons
haloperidol
Sign in to saveAlso known as Haloperidolum, Haldol®, MCN-JR-1625, R-1625, Serenace®, gamma-(4-(p-chlorophenyl)-4-hydroxpiperidino)-p-fluorbutyrophenone, 4'-fluoro-4-(4-(p-chlorophenyl)-4-hydroxypiperidinyl)butyrophenone, 4'-fluoro-4-(4-hydroxy-4-(4'-chlorophenyl)piperidino)butyrophenone
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal. It may be used by mouth or injection into a muscle or a vein. Haloperidol typically works within 30 to 60 minutes. A long-acting formulation may be used as an injection every four weeks for people with schizophrenia or related illnesses, who either forget or refuse to take the medication by mouth.
Key facts
- Drug.KEGG
- D00136
- Drug.ChEBI
- 5613
- Drug.ChEMBL
- 54
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464369120
- Drug.image
- Haloperidol.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250px
- Drug.image2
- Haloperidol-from-xtal-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250px
- Drug.tradename
- Haldol, others
- Drug.MedlinePlus
- a682180
- Drug.DailyMedID
- Haloperidol
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth, intramuscular, intravenous, depot (as decanoate ester)
- Drug.class
- Typical antipsychotic
- Drug.ATC_prefix
- N05
via Wikipedia infobox
Chemical data
- Formula
- C21H23ClFNO2
- Molecular weight
- 375.9 g/mol
- IUPAC name
- 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
- SMILES
- C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
- InChIKey
- LNEPOXFFQSENCJ-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 40.5 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
24,000 papersvia PubMed
Wikidata facts
- Mass
- 375.140135
Show 6 more facts
- Commons category
- Haloperidol
- chemical formula
- C₂₁H₂₃ClFNO₂
- MCN code
- 2933.39.15
- defined daily dose
- 8
- canonical SMILES
- C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
- World Health Organisation international non-proprietary name
- haloperidol
Sources (10)
via Wikidata · CC0
~19 min read
Article
28 sectionsContents
- Medical uses
- Pregnancy and lactation
- Other considerations
- Adverse effects
- Contraindications
- Special cautions
- Interactions
- Potential neurotoxicity
- Discontinuation
- Overdose
- Symptoms
- Treatment
- Prognosis
- Pharmacology
- Pharmacokinetics
- By mouth
- Intramuscular injections
- Intravenous injections
- Therapeutic concentrations
- Distribution and metabolism
- Chemistry
- History
- Society and culture
- Cost
- Names
- Research
- Veterinary use
- References
Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal. It may be used by mouth or injection into a muscle or a vein. Haloperidol typically works within 30 to 60 minutes. A long-acting formulation may be used as an injection every four weeks for people with schizophrenia or related illnesses, who either forget or refuse to take the medication by mouth.
Haloperidol may result in movement disorders such as tardive dyskinesia, and akathisia, both of which may be permanent. Neuroleptic malignant syndrome and QT interval prolongation may occur, the latter particularly with IV administration. In older people with psychosis due to dementia it results in an increased risk of death. When taken during pregnancy it may result in problems in the infant. It should not be used by people with Parkinson's disease.